Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer
Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer
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DOI：
10.1021/nl0714637
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发表时间：
2007-09-01
期刊：
影响因子：
10.8
通讯作者：
Prasad, Paras N.
中科院分区：
文献类型：
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作者：
Hulchanskyy, Tyrnish Y.;Roy, Indrajit;Prasad, Paras N.
我们报告了一种新型的光敏剂（PS）的纳米制剂，用于癌症的光动力疗法（PDT），其中PS分子共价结合到有机改性二氧化硅（ORMOSIL）纳米颗粒中。我们发现，共价结合的PS分子保留其光谱和功能特性，并可以鲁棒地产生细胞毒性的单线态氧分子的光照射。合成的纳米颗粒具有超低尺寸（类似于20 nm），并且在水悬浮液中高度单分散和稳定。这种共价连接的纳米纤维素提供的优点是药物在体循环过程中不会释放，这通常是物理封装的问题。这些纳米颗粒在体外也被肿瘤细胞大量摄取，并表现出光毒性作用，从而突出了它们在癌症诊断和PDT中的潜力。
We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size (similar to 20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.