Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndrome.
Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndrome.
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DOI：
10.1007/s00401-009-0535-y
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发表时间：
2009-10
影响因子：
12.7
通讯作者：
Kinney HC
中科院分区：
文献类型：
--
作者：
Rognum IJ;Haynes RL;Vege A;Yang M;Rognum TO;Kinney HC
Mild infection may trigger sudden death in the vulnerable infant by cytokine interactions with a compromised medullary serotonergic (5-HT) system, leading to disrupted cardiorespiratory regulation and sleep-related sudden death. The cytokine interleukin (IL)-6 is elevated in the cerebrospinal fluid in SIDS. We tested the hypothesis that the expression of IL-6 receptors (IL-6R) and/or gp130 (involved in IL-6R signaling) is altered in the medullary 5-HT system in SIDS. Immunohistochemistry of IL-6R and gp130 was performed on medullae from 25 SIDS infants, 20 infectious deaths, and 14 controls using a semi-quantitative grading system. In the SIDS cases, mean IL-6R intensity grade in the arcuate nucleus (major component of medullary 5-HT system) was significantly higher than in the control group (2.00 ± 0.07 vs. 1.77 ± 0.08, P = 0.04), with no other differences in IL-6R or gp130 expression at any other site. Arcuate 5-HT neurons expressed IL-6R, indicating a site of IL-6/5-HT interaction. In SIDS, IL-6R expression is abnormal in the arcuate nucleus, the putative human homolog of rodent ventral medullary chemosensitivity sites involving 5-HT. Aberrant interactions between IL-6 and the arcuate nucleus may contribute to impaired responses to hypercapnia generated by infection (hypermetabolism) combined with rebreathing.
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创伤后，通过上调白介素（IL）6和IL-6受体的表达来加速小鼠的神经再生。
影响因子：
15.3
作者：
Hirota, H;Kiyama, H;Kishimoto, T;Taga, T
通讯作者：
Taga, T
影响因子：
5.2
作者：
Mitchell, Edwin A.;Hutchison, Lynne;Stewart, Alistair W.
通讯作者：
Stewart, Alistair W.
影响因子：
5.1
作者：
KEMP, JS;KOWALSKI, RM;THACH, BT
通讯作者：
THACH, BT
DOI：
10.1016/s0034-5687(01)00295-x
发表时间：
2001-12-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Nattie, EE
通讯作者：
Nattie, EE
影响因子：
2.5
作者：
FILIANO, JJ;CHOI, JC;KINNEY, HC
通讯作者：
KINNEY, HC