The effect of ethanol on reversal learning in honey bees (Apis mellifera anatolica): Response inhibition in a social insect model
The effect of ethanol on reversal learning in honey bees (Apis mellifera anatolica): Response inhibition in a social insect model
复制标题
DOI：
10.1016/j.alcohol.2015.02.005
复制
发表时间：
2015-05-01
期刊：
影响因子：
2.3
通讯作者：
Wells, Harrington
中科院分区：
文献类型：
--
作者：
Abramson, Charles I.;Craig, David Philip Arthur;Wells, Harrington
研究了乙醇对蜜蜂逆向学习的影响。本实验的基本原理是确定乙醇对反应抑制作用的物种普遍性。在条件刺激被逆转之前，受试者最初被训练将肉桂或薰衣草气味与蔗糖喂养联系起来。我们给药15 μ L不同剂量的乙醇（0%,2.5%,5%，10%或20%）根据组分配。乙醇在原辨别训练前5分钟或刺激逆转前5分钟给予。我们通过最近开发的个体分析来分析这三种操作的影响，该分析避免了总体评估，而倾向于将学习概念化为个体生物的模型。我们测量了在与蔗糖喂食相关的条件刺激下的反应，在与蒸馏水相关的条件刺激下的反应，以及在非条件刺激（蔗糖）存在下的反应。我们的分析显示，在越来越高的剂量下，乙醇剂量操纵降低了所有三种措施的反应，这表明乙醇是一种一般的行为抑制剂。与之前的乙醇逆转文献一致，我们发现在最初的辨别阶段或逆转之前施用乙醇在不同乙醇剂量下产生不一致的反应模式。(C) 2015爱思唯尔公司版权所有。
We investigated the effects of ethanol on reversal learning in honey bees (Apis mellifera anatolica). The rationale behind the present experiment was to determine the species generality of the effect of ethanol on response inhibition. Subjects were originally trained to associate either a cinnamon or lavender odor with a sucrose feeding before a reversal of the conditioned stimuli. We administered 15 mu L of ethanol at varying doses (0%, 2.5%, 5%, 10%, or 20%) according to group assignment. Ethanol was either administered 5 min before original discrimination training or 5 min before the stimuli reversal. We analyzed the effects of these three manipulations via a recently developed individual analysis that eschews aggregate assessments in favor of a model that conceptualizes learning as occurring in individual organisms. We measured responding in the presence of conditioned stimuli associated with a sucrose feeding, responding in the presence of conditioned stimuli associated with distilled water, and responding in the presence of the unconditioned stimulus (sucrose). Our analyses revealed the ethanol dose manipulation lowered responding for all three measures at increasingly higher doses, which suggests ethanol served as a general behavioral suppressor. Consistent with previous ethanol reversal literature, we found administering ethanol before the original discrimination phase or before the reversal produced inconsistent patterns of responding at varying ethanol doses. (C) 2015 Elsevier Inc. All rights reserved.