DEMONSTRATION OF IGE AND IGG ANTIBODIES AGAINST VENOMS IN THE BLOOD OF VICTIMS OF FATAL STING ANAPHYLAXIS
DEMONSTRATION OF IGE AND IGG ANTIBODIES AGAINST VENOMS IN THE BLOOD OF VICTIMS OF FATAL STING ANAPHYLAXIS
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DOI：
10.1016/0091-6749(83)90099-4
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发表时间：
1983-01-01
影响因子：
14.2
通讯作者：
HUDSON, P
中科院分区：
文献类型：
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作者：
HOFFMAN, DR;WOOD, CL;HUDSON, P
1979-1981年，北卡罗来纳州[美国]有9人死于昆虫[Hyattera]叮咬过敏反应。对其中8例受试者的尸检血液标本进行了针对毒液的IgE和IgG抗体分析。所有18例患者对至少一种毒液的RAST [放射性过敏吸附试验]呈阳性。免疫球蛋白E和免疫球蛋白G抗蛇毒水平与一组未经治疗的刺痛过敏的个人。同时对几组对照血清进行了RAST，阳性率为3-50%，发病率最高的是北卡罗来纳州农村的户外工作者。蜇伤组RAST阳性率与对照组比较有显著性差异。这是第一次证明，在致命的过敏反应的受害者血清中的毒液IgE抗体从刺痛，并增加了进一步的证据，过敏反应中的作用IgE。
Nine people died from insect [Hymenoptera] sting anaphylaxis in North Carolina [USA] from 1979-1981. Postmortem blood specimens from 8 of these subjects were analyzed for IgE and IgG antibodies against venoms. ALl 8 were RAST [radioallergosorbent test] positive to at least 1 of the venoms. IgE and IgG anti-venom levels were comparable to those of a group of untreated sting-allergic individuals. RAST to venoms was also performed on several control groups of sera and from 3-50% positive RAST results were found. The highest incidence was in rural North Carolina outdoor workers. The incidence of positive RAST results in the sting-death group was significantly different from that in the control groups. This is the 1st demonstration of IgE antibodies against venoms in the sera of victims of fatal anaphylaxis from stings and adds further evidence for the role of IgE in sting anaphylaxis.