Adolescence: Vulnerable period for stress-induced prefrontal cortical function? - Introduction to Part IV
Adolescence: Vulnerable period for stress-induced prefrontal cortical function? - Introduction to Part IV
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DOI：
10.1196/annals.1308.017
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Shansky, RM
中科院分区：
文献类型：
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作者：
Arnsten, AFT;Shansky, RM
即使是轻微的无法控制的压力也会损害前额叶皮层的认知功能，这是一个对洞察力，判断和抑制不当行为至关重要的大脑区域。几个神经生物学因素可能有助于夸大的压力反应在青春期，例如，增加多巴胺能投射到前额叶皮质，并在女性中，增加循环雌激素，因为雌激素放大了许多方面的压力反应，并降低了阈值的压力诱导的前额叶皮质功能障碍。这些神经生物学因素可能会增加青春期判断力受损、药物成瘾和神经精神疾病的易感性。
Exposure to even mild uncontrollable stress impairs the cognitive functioning of the prefrontal cortex, a brain region critical for insight, judgment, and the inhibition of inappropriate behaviors. Several neurobiological factors may contribute to an exaggeration of the stress response in adolescence, for example, an increased dopaminergic projection to prefrontal cortex, and in females, increased circulating estrogen, as estrogen amplifies many aspects of the stress response and lowers the threshold for stress-induced prefrontal cortical dysfunction. These neurobiological factors may increase susceptibility to impaired judgment, drug addiction, and neuropsychiatric disorders during adolescence.