Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.
Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.
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DOI：
10.4049/jimmunol.1400936
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发表时间：
2014-09-01
期刊：
影响因子：
--
通讯作者：
Borghesi L
中科院分区：
文献类型：
--
作者：
Borghesi L
长期造血干细胞（LT-HSC）在整个生命过程中补充先天性和适应性免疫区室。虽然已经取得了重大进展，确定了主要的转录因子，调节谱系规范，结构蛋白，全球协调DNA甲基化，组蛋白修饰，基因表达的变化是很差的定义。新的研究将染色质组织者Satb 1确定为LT-HSC中的一种全球调节因子。Satb 1是一种核组织者，通过形成笼状结构来分配染色质。通过整合表观遗传和转录途径，Satb 1协调LT-HSC分裂，自我更新和淋巴潜能。在HSC中Satb 1控制下的基因分类中，出乎意料的是细胞因子，这一发现具有额外的重要性，这一发现具有挑衅性，即短期（ST-）HSC和下游多能祖细胞（MPP）在应激介导的造血过程中是有效的和生物学相关的细胞因子分泌物。这些研究共同揭示了一种新的命运调控机制和HSC不可预见的功能能力。
Long-term hematopoietic stem cells (LT-HSCs) replenish the innate and adaptive immune compartments throughout life. While significant progress has defined the major transcription factors that regulate lineage specification, the architectural proteins that globally coordinate DNA methylation, histone modification, and changes in gene expression are poorly defined. Provocative new studies establish the chromatin organizer Satb1 as one such global regulator in LT-HSCs. Satb1 is a nuclear organizer that partitions chromatin through the formation of cage-like structures. By integrating epigenetic and transcriptional pathways, Satb1 coordinates LT-HSC division, self-renewal, and lymphoid potential. Unexpected among the assortment of genes under Satb1 control in HSCs are cytokines, a finding that takes on additional importance with the provocative finding that short-term (ST-) HSCs and downstream multipotent progenitors (MPPs) are potent and biologically relevant cytokine secretors during stress-mediated hematopoiesis. Together these studies reveal a new mechanism of fate regulation and an unforeseen functional capability of HSCs.
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