Changes in Fatigue, Psychological Distress, and Quality of Life After Chemotherapy in Women with Breast Cancer A Prospective Study
Changes in Fatigue, Psychological Distress, and Quality of Life After Chemotherapy in Women with Breast Cancer A Prospective Study
复制标题
乳腺癌患者化疗后疲劳、心理困扰和生活质量的变化：一项前瞻性研究
DOI：
10.1097/ncc.0000000000000689
复制
发表时间：
2020-01-01
期刊：
影响因子：
2.6
通讯作者：
Cho, Jung-Ran
中科院分区：
文献类型：
--
作者：
Oh, Pok-Ja;Cho, Jung-Ran
背景化疗会导致各种症状和心理困扰，导致患者生活质量显着下降。目的 本研究的目的是确定乳腺癌女性癌症护理过程中疲劳-抑郁-焦虑症状群和生活质量的变化和相互关系。方法 50 名女性参与了该研究，并在化疗前、化疗后和化疗完成后 6 个月 3 个不同时间完成了问卷调查。评估工具为癌症治疗功能评估-疲劳量表、医院焦虑抑郁量表、癌症治疗功能评估-乳腺癌第四版量表。使用方差统计的描述性和重复测量分析来分析数据。结果 从化疗前到化疗后，疲劳（F = 41.95，P < .001）和心理困扰（F = 26.55，P < .001）显着增加。化疗完成后6个月观察到改善。疲劳的积极或消极变化与心理困扰相关。生活质量（F = 65.22，P < .001）也显示出与疲劳和心理困扰相似的变化模式。疲劳对化疗后的生活质量影响更大，但心理困扰对化疗前和 6 个月随访的影响更大。结论 这些结果表明化疗与乳腺癌女性的疲劳-抑郁-焦虑症状群和生活质量高度相关。
Background Chemotherapy leads to various symptoms and psychological distress, which contribute to a significant decrease in the quality of life of the patients. Objectives The aim of this study was to identify changes and interrelationships in the fatigue-depression-anxiety symptom cluster and quality of life during the cancer care trajectory in women with breast cancer. Methods Fifty women participated in the study and completed questionnaires at 3 different times: prechemotherapy, postchemotherapy, and 6 months after the completion of chemotherapy. The assessment tools were the Functional Assessment of Cancer Therapy-Fatigue Scale, Hospital Anxiety and Depression Scale, and Functional Assessment of Cancer Therapy-Breast Cancer version 4 Scale. Data were analyzed using descriptive and repeated-measures analysis of variance statistics. Results A significant increase in fatigue (F = 41.95, P < .001) and psychological distress (F = 26.55, P < .001) from prechemotherapy to postchemotherapy was noted. Improvement was observed 6 months after the completion of chemotherapy. A positive or negative change in fatigue was associated with the same in psychological distress. Quality of life (F = 65.22, P < .001) also showed similar change patterns as observed with fatigue and psychological distress. Fatigue had a greater impact on quality of life at postchemotherapy, but psychological distress had a greater impact at prechemotherapy and at the 6-month follow-up. Conclusion These results suggest that chemotherapy is highly associated with the fatigue-depression-anxiety symptom cluster and quality of life in women with breast cancer.