Coupling the cell cycle to cell growth -: A look at the parameters that regulate cell-cycle events
Coupling the cell cycle to cell growth -: A look at the parameters that regulate cell-cycle events
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DOI：
10.1038/sj.embor.embor895
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发表时间：
2003-08-01
期刊：
影响因子：
7.7
通讯作者：
Nordström, K
中科院分区：
文献类型：
--
作者：
Boye, E;Nordström, K
为了繁殖，原核细胞和真核细胞都经历了一系列事件，这些事件统称为细胞周期。然而，DNA复制、有丝分裂和细胞分裂也可能被视为有自己的、原则上独立的周期，这些周期通过细胞周期外部的机制--检查点--联系在一起，维持事件的顺序。我们认为，通过将每个事件单独视为一个独立调节的过程，我们对细胞周期调控的理解得到了加强。讨论了调节细胞周期事件的参数的性质，特别是，我们认为细胞质量不是这样的参数。
In order to multiply, both prokaryotic and eukaryotic cells go through a series of events that are collectively called the cell cycle. However, DNA replication, mitosis and cell division may also be viewed as having their own, in principle independent, cycles, which are tied together by mechanisms extrinsic to the cell cycle - the checkpoints - that maintain the order of events. We propose that our understanding of cell-cycle regulation is enhanced by viewing each event individually, as an independently regulated process. The nature of the parameters that regulate cell-cycle events is discussed and, in particular, we argue that cell mass is not such a parameter.