Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study.
Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study.
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DOI：
10.1186/s12967-022-03407-6
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发表时间：
2022-05-13
影响因子：
7.4
通讯作者：
Huang, Yinong
中科院分区：
文献类型：
--
作者：
Chen, Xiong;Hong, Xiaosi;Gao, Wenjing;Luo, Shulu;Cai, Jiahao;Liu, Guochang;Huang, Yinong
关键词：
2019年冠状病毒病大流行（COVID-19）对全球公共卫生构成巨大威胁，随之而来的社会隔离管理大大减少了体力活动（PA）的机会，并增加了休闲久坐行为（LSB）的机会。鉴于PA和LSB已被确定为肥胖、糖尿病和心脏代谢综合征的主要影响因素，PA/LSB是否会通过破坏代谢稳态进而影响对COVID-19的易感性仍有待探索。在这项研究中，我们旨在使用孟德尔随机化研究系统地评估PA/LSB与COVID-19易感性、住院和严重程度之间的因果关系。数据来自大规模PA数据集（N = 377，000）、LSB数据集（N = 422，218）和COVID-19宿主遗传学倡议（N = 2，586，691）。因果效应的估计采用逆方差加权法、MR-Egger法、加权中位数法和MR-EMO法。敏感性分析采用Cochran’s Q检验、MR-Egger截距检验、MR-EGO、留一分析和漏斗图。进一步进行风险因素分析，以调查潜在的介质。遗传预测加速度计评估的PA降低了COVID-19住院治疗的风险（OR = 0.93，95%CI 0.88-0.97; P = 0.002），而休闲看电视显著增加了COVID-19住院的风险（OR = 1.55，95%CI 1.29-1.88; P = 4.68 × 10-6）和疾病严重程度（OR = 1.85，95%CI 1.33-2.56; P = 0.0002）。未观察到自我报告的中度至剧烈体力活动（MVPA）、加速度计加速度分数> 425毫重力、使用电脑或驾驶对COVID-19进展的因果影响。危险因素分析表明，上述因果关系可能是由几个代谢危险因素介导的，包括吸烟、高体重指数、血清甘油三酯水平升高、胰岛素抵抗和2型糖尿病的发生。我们的研究结果支持了加速度计评估的PA对降低COVID-19住院风险的因果关系，以及观看电视对增加COVID-19住院风险和严重程度的因果关系，这可能是由吸烟，肥胖和2型糖尿病相关表型介导的。在COVID-19隔离检疫期间，应特别注意减少休闲久坐行为，并鼓励适当运动。在线版本包含补充材料，可通过10.1186/s12967-022-03407-6获得。
The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (PA) and increased opportunities for leisure sedentary behaviors (LSB). Given that both PA and LSB have been established as major influencing factors for obesity, diabetes and cardiometabolic syndrome, whether PA/LSB in turn affects the susceptibility to COVID-19 by disrupting metabolic homeostasis remains to be explored. In this study, we aimed to systematically evaluate the causal relationship between PA/LSB and COVID-19 susceptibility, hospitalization and severity using a Mendelian randomization study. Data were obtained from a large-scale PA dataset (N = 377,000), LSB dataset (N = 422,218) and COVID-19 Host Genetics Initiative (N = 2,586,691). The causal effects were estimated with inverse variance weighted, MR-Egger, weighted median and MR-PRESSO. Sensitivity analyses were implemented with Cochran’s Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis and the funnel plot. Risk factor analyses were further conducted to investigate the potential mediators. Genetically predicted accelerometer-assessed PA decreased the risk for COVID-19 hospitalization (OR = 0.93, 95% CI 0.88–0.97; P = 0.002), while leisure television watching significantly increased the risk of COVID-19 hospitalization (OR = 1.55, 95% CI 1.29–1.88; P = 4.68 × 10–6) and disease severity (OR = 1.85, 95% CI 1.33–2.56; P = 0.0002) after Bonferroni correction. No causal effects of self-reported moderate to vigorous physical activity (MVPA), accelerometer fraction of accelerations > 425 milligravities, computer use or driving on COVID-19 progression were observed. Risk factor analyses indicated that the above causal associations might be mediated by several metabolic risk factors, including smoking, high body mass index, elevated serum triglyceride levels, insulin resistance and the occurrence of type 2 diabetes. Our findings supported a causal effect of accelerometer-assessed PA on the reduced risk of COVID-19 hospitalization as well as television watching on the increased risk of COVID-19 hospitalization and severity, which was potentially mediated by smoking, obesity and type 2 diabetes-related phenotypes. Particular attention should be given to reducing leisure sedentary behaviors and encouraging proper exercise during isolation and quarantine for COVID-19. The online version contains supplementary material available at 10.1186/s12967-022-03407-6.
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影响因子：
11.1
作者：
Chen X;Kong J;Pan J;Huang K;Zhou W;Diao X;Cai J;Zheng J;Yang X;Xie W;Yu H;Li J;Pei L;Dong W;Qin H;Huang J;Lin T
通讯作者：
Lin T
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
DOI：
10.1038/s41366-018-0120-3
发表时间：
2018-06
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Klimentidis YC;Raichlen DA;Bea J;Garcia DO;Wineinger NE;Mandarino LJ;Alexander GE;Chen Z;Going SB
通讯作者：
Going SB
影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
7.7
作者：
Hamilton, Marc T.;Hamilton, Deborah G.;Zderic, Theodore W.
通讯作者：
Zderic, Theodore W.