p53 mutations implicate sunlight in post-transplant skin cancer irrespective of human papillomarivus status
p53 mutations implicate sunlight in post-transplant skin cancer irrespective of human papillomarivus status
复制标题
p53突变与移植后皮肤癌有关，无论人乳头状瘤状态如何
作者：
J. McGregor;R. Berkhout;M. Rozycka;J. Schegget;J. Bavinck;L. Brooks;T. Crook
在肾移植受者的非黑色素瘤皮肤癌中有11/23(48%)检测到P53基因突变，在免疫功能正常的患者中有5/8(63%)的散发性肿瘤中检测到P53突变。移植患者中9/12(75%)的突变和非移植肿瘤中的所有5种突变与紫外线(UV)造成的损伤一致。辐射。在9/23(39%)的移植肿瘤和2/8(25%)的非移植肿瘤中检测到DNA序列，主要是疣状表皮发育不良(EV)亚型。P53突变与HPV状态无关，P53突变阳性肿瘤中HPVDNA阳性5/16(31%)，P53突变阴性肿瘤中HPVDNA阳性6/15(40%)。这些数据与阳光在移植后皮肤癌发生中的重要作用是一致的，而且有限的功能数据表明，皮肤和EV相关乳头状瘤病毒的E6蛋白并不针对泛素介导的降解P53。
Mutations in p53 were detected in 11/23 (48%) of non melanoma skin cancers in renal allograft recipients and in 5/8 (63%) of sporadic tumours from immune competent patients. 9/12 (75%) of mutations in transplant patients and all 5 mutations in non transplant tumours were consistent with damage caused by ultraviolet (u.v.) irradiation. DNA sequences, predominantly of the epidermodysplasia verruciformis (EV) subgroup, were detected in 9/23 (39%) of transplant tumours and in 2/8 (25%) of eight non-transplant tumours. There was no relationship between HPV status and p53 mutation, HPV DNA being present in 5/16 (31%) of tumours with p53 mutation and 6/15 (40%) of tumours lacking p53 mutation. These data are consistent with an important role for sunlight in the development of post-transplant skin cancer, and with limited functional data suggesting that E6 proteins of the cutaneous and EV-related papillomaviruses do not target p53 for ubiquitin-mediated degradation.