Arthrogryposis, hydranencephaly and cerebellar hypoplasia syndrome in neonatal calves resulting from intrauterine infection with Aino virus
Arthrogryposis, hydranencephaly and cerebellar hypoplasia syndrome in neonatal calves resulting from intrauterine infection with Aino virus
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DOI：
10.1051/vetres:2004029
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发表时间：
2004-09-01
影响因子：
4.4
通讯作者：
Yamakawa, M
中科院分区：
文献类型：
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作者：
Tsuda, T;Yoshida, K;Yamakawa, M
为了解禽流感病毒(AINOV)对牛的致畸作用，用AINOV新鲜分离株感染妊娠牛和胎牛。在怀孕122至162天时，5头怀孕的奶牛被静脉接种该病毒，并允许分娩。所有奶牛都产生了病毒的中和抗体，表明奶牛已经感染了病毒；然而，在他们的六头新生牛犊中没有发现临床异常，在牛初乳前血清中也没有检测到针对该病毒的特异性抗体。对5例胎龄132~156天的胎儿宫内接种该病毒。1头弱小新生儿和4头死产小牛出生于妊娠256-263天，即小于标准孕期；他们都有先天性畸形，包括关节畸形、无脑积水和小脑发育不全。在他们的初乳前血清中检测到了针对AINOV的特异性抗体。这些结果表明，AINOV是一种潜在的牛先天性畸形的病原体。
To determine the teratogenic potential of Aino virus (AINOV) in cattle, pregnant cows and fetal cattle were infected with a fresh isolate of AINOV. Five pregnant cows were inoculated intravenously with the virus at 122 to 162 days of gestation and allowed to give birth. All of the cows developed neutralizing antibodies to the virus, indicating that the cows had been infected with the virus; however, no clinical abnormalities were seen in their six newborn calves, and no specific antibodies to the virus were detected in the precolostral serum of calves. Five fetuses with fetal ages ranging from 132 to 156 days were inoculated in utero with the virus. One weak newborn and four stillborn calves were delivered at gestation days 256 to 263, i.e., less than the standard gestation term; they had congenital abnormalities including arthrogryposis, hydranencephaly and cerebellar hypoplasia. Antibodies specific to AINOV were detected in their precolostral serum. These results demonstrate that AINOV is a potential etiological agent of congenital malformation of cattle.