Effect of reduced pressure on the polarization of 129Xe in the production of hyperpolarized 129Xe gas:: Development of a simple continuous flow mode hyperpolarizing system working at pressures as low as 0.15 atm
Effect of reduced pressure on the polarization of 129Xe in the production of hyperpolarized 129Xe gas:: Development of a simple continuous flow mode hyperpolarizing system working at pressures as low as 0.15 atm
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DOI：
10.1002/cmr.b.20117
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发表时间：
2008-08-01
影响因子：
0.9
通讯作者：
Fujiwara, Hideaki
中科院分区：
文献类型：
--
作者：
Imai, Hirohiko;Fukutomi, Junko;Fujiwara, Hideaki
在间歇和连续流动模式下研究了减压对 Xe-129 极化的影响，旨在开发一种简单方便的超极化系统。研究发现，与接近大气压时相比，在低至 0.15 个大气压的减压下，外来气体的影响表现出不同的趋势。例如，与相同 Xe 含量相比，Xe 和 N-2 二元混合物中的 Xe-129 极化大于 Xe、N2 和 4 He 三元混合物中观察到的极化，并且批处理模式下 5% Xe + 95% N2 混合物的最高极化率为 63.6%。流动模式中最显着的结果是，当电池压力从大气压降低时，Xe-129 极化在 0.15 atm 处达到稳定状态，增强到接近大气压时观察到的大约两倍。还演示了在降低的分压下使用富含同位素的 129Xe 气体。这将避免氙气的麻醉副作用，同时利用减压增强极化，从而开发出一种简单方便的医用超极化系统。 (C) 2008 年 Wiley 期刊公司。
The effect of reduced pressure on the polarization of Xe-129 has been examined in batch and continuous flow modes aiming at developing a simple and convenient hyperpolarizing system. The effect of foreign gases was found to show a different tendency at reduced pressure as low as 0.15 atm compared to that near atmospheric pressure. For example, Xe-129 polarization in binary mixtures of Xe and N-2 was larger than that observed in ternary mixtures of Xe, N2, and 4 He when compared with the same Xe content, and the highest polarization of 63.6% was given by the 5% Xe + 95% N2 mixture in the batch mode. The most noticeable result in the flow mode was that Xe-129 polarization reached a plateau at 0.15 atm when cell pressure was reduced from atmospheric pressure, being enhanced to about twice of that observed near atmospheric pressure. Also demonstrated is the use of isotopically enriched 129Xe gas at reduced partial pressure. This will be devoid of the anesthetic side effects of Xe while making use of enhanced polarization at reduced pressure, leading to the development of a simple and convenient hyperpolarizing system for medical use. (C) 2008 Wiley Periodicals, Inc.