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DOI：
10.1080/00856401.2016.1238030
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发表时间：
2017-04
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组织相容性系统是同种异体移植排斥反应的主要机制。该系统的存在是为了对抗病毒复制的爆炸性速度。它通过将细胞毒性T细胞的防御性免疫攻击引导到受感染细胞表面的组织相容性抗原上来实现这一点。这使得在细胞毒性T细胞被无数的新病毒体淹没之前，被感染细胞所成为的病毒工厂被破坏，每10小时有1000个新病毒体来自每个被感染细胞。免疫系统将同种异体抗原误认为是需要迅速破坏的病毒感染的宿主细胞。对于移植，Sykes改进了Kaplan的技术，将受体骨髓细胞添加到注射的供体骨髓细胞中，用于在免疫消融后重建受体。该方案应该能够从未经处理的猪中进行异种移植，为人类提供即时和无限的移植物供应。
The histocompatibility system is responsible for the rejection of allograft. The system exists to counter the explosive speed of viral replication. It does this by directing the defensive immune attack by cytotoxic T cells on to histocompatibility antigens on the infected cell’s surface. This enables destruction of the virus factories that the infected cells become, before the cytotoxic T cells are swamped by the myriad numbers of new virions, a thousand coming from each infected cell every 10 hours. The immunity system mistakes alloantigens for virus infected host cells that need swift destruction. For transplantation, Sykes has improved Kaplan’s technique by adding recipient bone marrow cells to the donor ones injected for reconstitution of the recipient after immune ablation. This protocol should enable xenografting from untreated pigs, offering instant and unlimited supply of grafts for man.