Diversity synthesis of pyrimido[4,5-b][1,6]naphthyridine and its derivatives under microwave irradiation.
Diversity synthesis of pyrimido[4,5-b][1,6]naphthyridine and its derivatives under microwave irradiation.
复制标题
DOI：
10.1021/cc800196u
复制
发表时间：
2009-08
影响因子：
--
通讯作者：
Z. Han;Ge Zhang;Bo Jiang;N. Ma;F. Shi;S. Tu
中科院分区：
文献类型：
--
作者：
Z. Han;Ge Zhang;Bo Jiang;N. Ma;F. Shi;S. Tu
摘要在微波辐射下，以3,5-二苄基吡啶-4- 1与各种类胺（2,6-二氨基吡啶-4(3H)- 1,3 -氨基-5,5-二甲基环己-2-烯酮、3-甲基-1-苯基- 1h -吡唑-5-胺和1h -苯并[d]咪唑-2-胺）在乙二醇中反应，成功合成了一系列含有嘧啶[4,5-b][1,6]-、苯并[1,6]-、吡啶[3,4-b][1,6] -、杂环芴骨架的杂环化合物。该方法具有合成路线短、操作简单、安全性高的优点，可用于生物医学筛选的小范围快速合成。
A series of new heterocyclic compounds, involving pyrimido[4,5-b][1,6]-, benzo[b][1,6]-, pyrazolo[3,4-b][1,6]naphthyridine, and aza-benzo[b]fluorene skeletons were successfully synthesized via the reaction of structurally diverse 3,5-dibenzylidenepiperidin-4-one with various enamine-likes (2,6-diaminopyrimidin-4(3H)-one, 3-amino-5,5-dimethylcyclohex-2-enone, 3-methyl-1-phenyl-1H-pyrazol-5-amine and 1H-benzo[d]imidazol-2-amine) in glycol under microwave irradiation. This method has the advantages of short synthetic route, operational simplicity, and increased safety for small-scale fast synthesis for biomedical screening.