The risk of birth defects among children of Persian Gulf War veterans
The risk of birth defects among children of Persian Gulf War veterans
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DOI：
10.1056/nejm199706053362306
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发表时间：
1997-06-05
影响因子：
158.5
通讯作者：
Wishik, SM
中科院分区：
文献类型：
--
作者：
Cowan, DN;DeFraites, RF;Wishik, SM
有人怀疑，在波斯湾战争中服役对退伍军人的健康产生了不利影响，并声称这些退伍军人的子女中出生缺陷的比率有所增加。方法对1991年、1992年和1993年135家军队医院常规收集的所有活产数据进行分析。该数据库包括每次出生住院的国际疾病分类第9版临床修改（ICD-9-CM）中多达8项诊断，以及父母的人口统计学特征和服务史信息。对75,000多名新生儿的记录进行了评估，以确定任何出生缺陷（ICD-9-CM代码740至759，加上肿瘤和遗传性疾病）以及根据疾病控制和预防中心的具体诊断和标准确定为严重的出生缺陷。结果在研究期间，在军事医院，33,998名海湾战争退伍军人和41,463名非部署退伍军人所生婴儿。任何出生缺陷的总体风险为7.45%，严重出生缺陷的风险为1.85%。这些比率与报告的平民人口比率相似。在多变量分析中，无论是男性还是女性，在海湾战争中服役与他们的孩子有任何出生缺陷或严重出生缺陷的风险之间都没有显著的联系。该分析没有发现海湾战争退伍军人子女出生缺陷风险增加的证据。(C) 1997年，马萨诸塞州医学协会。
Background There has been suspicion that service in the Persian Gulf War affected the health of veterans adversely, and there have been claims of an increased rate of birth defects among the children of those veterans.Methods We evaluated the routinely collected data on all live births at 135 military hospitals in 1991, 1992, and 1993. The data base included up to eight diagnoses from the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) for each birth hospitalization, plus information on the demographic characteristics and service history of the parents. The records of over 75,000 newborns were evaluated for any birth defect (ICD-9-CM codes 740 to 759, plus neoplasms and hereditary diseases) and for birth defects defined as severe on the basis of the specific diagnoses and the criteria of the Centers for Disease Control and Prevention.Results During the study period, 33,998 infants were born to Gulf War veterans and 41,463 to nondeployed veterans at military hospitals. The overall risk of any birth defect was 7.45 percent, and the risk of severe birth defects was 1.85 percent. These rates are similar to those reported in civilian populations. In the multivariate analysis, there was no significant association for either men or women between service in the Gulf War and the risk of any birth defect or of severe birth defects in their children.Conclusions This analysis found no evidence of an increase in the risk of birth defects among the children of Gulf War veterans. (C) 1997, Massachusetts Medical Society.