A chemoselective biomolecular template for assembling diverse nanotubular materials
A chemoselective biomolecular template for assembling diverse nanotubular materials
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DOI：
10.1088/0957-4484/13/4/318
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发表时间：
2002-08-01
期刊：
影响因子：
3.5
通讯作者：
Stowell, MHB
中科院分区：
文献类型：
--
作者：
Demir, M;Stowell, MHB
我们描述了一种烟草花叶病毒突变体的设计和生产，该突变体提供了多种配体-接头基团的特异性和化学计量的连接。因此，特定的配体可以化学选择性地连接到病毒体，以产生高度多样化的纳米分子材料。这些包括半晶体蛋白质阵列和金属“纳米管”，以及纳米分子“光棒”。所描述的方法是方便和廉价的，在纳米纤维和生物分子结构测定等不同领域的潜在用途。
We describe the design and production of a tobacco mosiac virus mutant that provides for specific and stoichiometric attachment of a wide variety of ligand-linker groups. As a result, specific ligands could be chemoselectively linked to the virion to produce highly diverse nanomolecular materials. These included semi-crystalline protein arrays and metallic 'nanopipes', as well as nanomolecular 'light sticks'. The method described is facile and inexpensive with potential uses in such diverse areas as nanofabrication and biomolecular structure determination.