Mast Cell: A Multi-Functional Master Cell.
Mast Cell: A Multi-Functional Master Cell.
复制标题
DOI：
10.3389/fimmu.2015.00620
复制
发表时间：
2015
影响因子：
7.3
通讯作者：
Wood JG
中科院分区：
文献类型：
--
作者：
Krystel-Whittemore M;Dileepan KN;Wood JG
肥大细胞是骨髓系的免疫细胞，存在于全身结缔组织中。肥大细胞的激活和脱颗粒显著调节各种情况下的生理和病理条件的许多方面。就正常生理功能而言，肥大细胞调节血管舒张、血管稳态、先天和适应性免疫反应、血管生成和毒液解毒。另一方面，肥大细胞也与许多疾病的病理生理有关，包括过敏、哮喘、过敏反应、胃肠道疾病、许多类型的恶性肿瘤和心血管疾病。本文综述了肥大细胞在许多病理生理条件下的作用。
Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells are known to regulate vasodilation, vascular homeostasis, innate and adaptive immune responses, angiogenesis, and venom detoxification. On the other hand, mast cells have also been implicated in the pathophysiology of many diseases, including allergy, asthma, anaphylaxis, gastrointestinal disorders, many types of malignancies, and cardiovascular diseases. This review summarizes the current understanding of the role of mast cells in many pathophysiological conditions.