Integration of goal- and stimulus-related visual signals revealed by damage to human parietal cortex.
Integration of goal- and stimulus-related visual signals revealed by damage to human parietal cortex.
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DOI：
10.1523/jneurosci.0997-10.2010
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发表时间：
2010-04-28
期刊：
影响因子：
--
通讯作者：
Husain M
中科院分区：
文献类型：
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作者：
Bays PM;Singh-Curry V;Gorgoraptis N;Driver J;Husain M
我们看向哪里既取决于我们当前的意图，也取决于视觉上突出的物品“吸引我们的眼球”的倾向。顶叶皮层受损后，引导注意力的正常过程往往严重受损。在这里，我们跟踪顶叶患者在视觉搜索过程中的眼球运动，以分别映射目标定向到目标的障碍，以及刺激驱动的凝视转移到突出但与任务无关的探针。这两种不同类型的注意力选择的缺陷被证明是相同的幅度和空间分布，符合损害的“优先级地图”，集成目标和刺激相关的信号，以选择视觉目标。当目标相关和视觉显著的项目竞争的注意，结果取决于一个有偏见的竞争，其中的优先级contralesional目标被低估。在此基础上，我们进一步证明顶叶患者在目标导向视觉探索中的空间偏差（忽视）可以通过系统地操纵视觉阵列中刺激显著性的空间分布来纠正甚至逆转。
Where we look is determined both by our current intentions and by the tendency of visually-salient items to ‘catch our eye’. Following damage to parietal cortex, the normal process of directing attention is often profoundly impaired. Here, we tracked parietal patients’ eye movements during visual search to separately map impairments in goal-directed orienting to targets, versus stimulus-driven gaze shifts to salient but task-irrelevant probes. Deficits in these two distinct types of attentional selection are shown to be identical in both magnitude and spatial distribution, consistent with damage to a ‘priority map’ that integrates goal- and stimulus-related signals to select visual targets. When goal-relevant and visually-salient items compete for attention, the outcome depends on a biased competition in which the priority of contralesional targets is undervalued. On the basis of these findings, we further demonstrate that parietal patients’ spatial bias (neglect) in goal-directed visual exploration can be corrected and even reversed by systematically manipulating the spatial distribution of stimulus salience in the visual array.