Association Between Low-Density Lipoprotein Cholesterol Levels and Risk for Sepsis Among Patients Admitted to the Hospital With Infection
Association Between Low-Density Lipoprotein Cholesterol Levels and Risk for Sepsis Among Patients Admitted to the Hospital With Infection
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DOI：
10.1001/jamanetworkopen.2018.7223
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发表时间：
2019-01-01
影响因子：
13.8
通讯作者：
Stein, C. Michael
中科院分区：
文献类型：
--
作者：
Feng, QiPing;Wei, Wei-Qi;Stein, C. Michael
低密度脂蛋白胆固醇(LDL-C)水平低是否与败血症风险增加和预后较差相关尚不清楚。目的检查住院感染患者中低密度脂蛋白胆固醇(LDL-C)水平与脓毒症风险之间的关系。设计、设置和参与者队列研究，其中使用明确的电子健康记录来定义田纳西州纳什维尔范德比尔特大学医学中心入院的感染患者的队列。患者是成年白人，具有国际疾病分类第九版临床修改中指示感染的代码，并在入院后1天内接受抗生素治疗(N=61 502)。收集了1993年1月1日至2017年12月31日的数据，并对2018年1月24日至10月31日的数据进行了分析。干预措施临床测量的低密度脂蛋白水平(不包括所有测量的值。05)。低密度脂蛋白胆固醇GRS与测得的低密度脂蛋白胆固醇水平相关(r=0.24；P
IMPORTANCE Whether lowlevels of low-density lipoprotein cholesterol (LDL-C) are associated with increased risk of sepsis and poorer outcomes is unknown.OBJECTIVE To examine the association between LDL-C levels and risk of sepsis among patients admitted to the hospital with infection.DESIGN, SETTING, AND PARTICIPANTS Cohort study in which deidentified electronic health records were used to define a cohort of patients admitted to Vanderbilt University Medical Center, Nashville, Tennessee, with infection. Patients were white adults, had a code indicating infection from the International Classification of Diseases, Ninth Revision, Clinical Modification, and received an antibiotic within 1 day of hospital admission (N=61 502). Data were collected from January 1, 1993, through December 31, 2017, and analyzed from January 24 through October 31, 2018.INTERVENTIONS Clinically measured LDL-C levels (excluding measurements.05 for all). The LDL-C GRS correlated with measured LDL-C levels (r=0.24; P