The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information
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DOI：
10.7554/elife.56694
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发表时间：
2020-06-22
期刊：
影响因子：
7.7
通讯作者：
Ding, Long
中科院分区：
文献类型：
--
作者：
Doi, Takahiro;Fan, Yunshu;Ding, Long
我们的决定通常会平衡我们观察到的和我们想要的。实现这一复杂的平衡行为的一个主要候选者是基底神经节通路，但它的作用尚未得到详细的实验研究。在这里，我们表明，基底节的一个主要输入站，尾状核，在整合不确定的视觉证据和奖励背景以指导适应性决策方面发挥了因果作用。在根据运动线索和不对称的奖赏选择关联做出扫视决定的猴子中，单个尾状神经元编码了这两种信息来源。在观看运动时，尾状核部位的微刺激影响了猴子的决定。这些微刺激效应包括决策过程中多个计算成分的协调变化，这些变化模仿了猴子平衡视觉和奖励信息的类似协调的自愿策略。这些结果表明，尾状核在协调平衡外部证据和内部偏好的决策过程中发挥因果作用。
Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nucleus, plays a causal role in integrating uncertain visual evidence and reward context to guide adaptive decision-making. In monkeys making saccadic decisions based on motion cues and asymmetric reward-choice associations, single caudate neurons encoded both sources of information. Electrical microstimulation at caudate sites during motion viewing affected the monkeys' decisions. These microstimulation effects included coordinated changes in multiple computational components of the decision process that mimicked the monkeys' similarly coordinated voluntary strategies for balancing visual and reward information. These results imply that the caudate nucleus plays causal roles in coordinating decision processes that balance external evidence and internal preferences.