Model for Porosity Changes Occurring during Ultrasound-Enhanced Transcorneal Drug Delivery.
Model for Porosity Changes Occurring during Ultrasound-Enhanced Transcorneal Drug Delivery.
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DOI：
10.1016/j.ultrasmedbio.2017.01.013
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发表时间：
2017-06
影响因子：
2.9
通讯作者：
Myers M
中科院分区：
文献类型：
--
作者：
Hariharan P;Nabili M;Guan A;Zderic V;Myers M
Ultrasound-enhanced drug delivery through the cornea has considerable therapeutic potential. However, our understanding of how ultrasound enhances drug transport is poor, as is our ability to predict the increased level of transport for given ultrasound parameters. This paper describes a computational model for quantifying changes in corneal porosity during ultrasound exposure. The model is calibrated through experiments involving sodium fluorescein transport through rabbit cornea. Validation was performed using nylon filters, for which the properties are known. It was found that exposure to 800 kHz ultrasound at intensity 2 W/cm2 for 5 minutes increased the porosity of the epithelium by a factor of 5. The model can be useful for determining the extent to which ultrasound enhances the amount of drug transported through biological barriers, and the time at which therapeutic dose is achieved at a given location, for different drugs and exposure strategies.
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