Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames
Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames
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DOI：
10.1126/science.1238802
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发表时间：
2013-09-06
期刊：
影响因子：
56.9
通讯作者：
Couso, Juan Pablo
中科院分区：
文献类型：
--
作者：
Magny, Emile G.;Pueyo, Jose Ignacio;Couso, Juan Pablo
小的开放阅读框（smorf）是短的DNA序列，能够编码少于100个氨基酸的小肽。尽管我们的基因组中存在数千个元素，但对这些元素的研究一直被忽视。我们和其他人之前已经证明，短至11个氨基酸的肽在昆虫发育过程中被翻译并提供必要的功能。在这里，我们描述了两个少于30个氨基酸的肽调节钙运输，从而影响正常的肌肉收缩，在果蝇心脏。这些肽似乎在从苍蝇到人类的一系列物种中保存了5.5亿年以上，其中它们与心脏疾病有关。这种保守表明，心脏调节的机制是古老的，smorf可能是一个基本的基因组组成部分，应该进行系统研究。
Small open reading frames (smORFs) are short DNA sequences that are able to encode small peptides of less than 100 amino acids. Study of these elements has been neglected despite thousands existing in our genomes. We and others previously showed that peptides as short as 11 amino acids are translated and provide essential functions during insect development. Here, we describe two peptides of less than 30 amino acids regulating calcium transport, and hence influencing regular muscle contraction, in the Drosophila heart. These peptides seem conserved for more than 550 million years in a range of species from flies to humans, in which they have been implicated in cardiac pathologies. Such conservation suggests that the mechanisms for heart regulation are ancient and that smORFs may be a fundamental genome component that should be studied systematically.