Leptin and ghrelin levels in patients with obstructive sleep apnea syndrome
Leptin and ghrelin levels in patients with obstructive sleep apnea syndrome
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DOI：
10.1159/000086254
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发表时间：
2005-01-01
期刊：
影响因子：
3.7
通讯作者：
Bilgihan, A
中科院分区：
文献类型：
--
作者：
Ciftci, TU;Kokturk, O;Bilgihan, A
背景：瘦素是一种被广泛研究的与人体组成、能量稳态和摄食行为有关的激素。阻塞性睡眠呼吸暂停综合征（OSAS）与肥胖密切相关，而肥胖与高瘦素血症密切相关。最近，人们发现了胃饥饿素，一种同样影响食欲和能量平衡的激素。目的：本研究的目的是研究伴有OSAS的肥胖患者的血清瘦素和胃饥饿素水平，并与没有OSAS的同样肥胖的对照组进行比较。方法：30例未经治疗的中重度OSAS肥胖患者（呼吸暂停-低通气指数：AHI >= 15）和22例肥胖对照（AHI = 15）
Background: Leptin is a hormone with well-investigated functions concerning body composition, energy homeostasis and feeding behavior in humans. The obstructive sleep apnea syndrome (OSAS) is strongly associated with obesity, which is known to be closely associated with hyperleptinemia. More recently, ghrelin, a hormone that also influences appetite and energy homeostasis, has been discovered. Objectives: The aim of this study was to investigate serum leptin and ghrelin levels in obese patients with OSAS in comparison with equally obese controls without OSAS. Methods: Thirty untreated obese patients with moderate-severe OSAS (apnea-hypopnea index: AHI >= 15) and 22 obese controls (AHI