The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures.
The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures.
复制标题
抗组胺药在原代肝细胞培养物中诱导非计划 DNA 合成。
DOI：
10.1016/0304-3835(80)90067-1
复制
发表时间：
1980
期刊：
影响因子：
9.7
通讯作者：
S. B. Neal
中科院分区：
文献类型：
--
作者：
G. Probst;S. B. Neal
在成年大鼠肝细胞原代培养物中化学诱导的、计划外的DNA合成的放射自显影鉴定目前正被验证为诱变剂/致癌物的预测试验。8种抗组胺药中，2种，马来酸吡咯胺和盐酸三烯胺，对计划外DNA合成呈阳性。建议在替代测试系统中进一步研究这些化合物的致突变/致癌潜力。
The autoradiographic identification of chemically-induced, unscheduled DNA synthesis in primary cultures of adult rat hepatocytes is currently being validated as a predictive test for mutagens/carcinogens. Of 8 antihistaminic drugs tested, 2, pyrilamine maleate and tripelennamine HCl, were positive for unscheduled DNA synthesis. Further investigation of the mutagenic/carcinogenic potential of these compounds in alternate test systems is suggested.