Effect of the Natural Product Triptolide on Pancreatic Cancer: A Systematic Review of Preclinical Studies.
Effect of the Natural Product Triptolide on Pancreatic Cancer: A Systematic Review of Preclinical Studies.
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天然产物雷公藤内酯醇对胰腺癌的作用：临床前研究的系统评价
DOI：
10.3389/fphar.2017.00490
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发表时间：
2017
影响因子：
5.6
通讯作者：
Lu AP
中科院分区：
文献类型：
--
作者：
Zhang C;He XJ;Li L;Lu C;Lu AP
目的：雷公藤内酯醇（TL）是从雷公藤（Tripterygium wilfordii Hook F，TwHF）中分离得到的一种天然产物，在体内外均表现出较强的抗肿瘤作用。我们的目的是总结的生化机制，通过TL已被证明是诱导细胞凋亡，自噬和抑制血管生成的胰腺癌（PC）。方法：我们对临床前证据进行了系统回顾。我们搜索了电子数据库。其潜在的作用机制和信号通路也已被积累。结果：我们筛选了116篇摘要的合格性，并在分析中纳入了17项临床前研究。16项研究（94.1%）提供了动物和细胞系的详细信息。6项研究（75.0%）将动物随机分配至给药组或对照组，仅1项研究（12.5%）报告设盲。TL的研究领域主要集中在其通过下调抑制途径和上调凋亡途径的促凋亡作用。研究表明，TL在体外和体内均对PC细胞有效。结论：本研究对TL的抗胰腺癌作用及其机制进行了系统的总结，特别强调了细胞凋亡、自噬、血管生成及相关分子通路。在治疗分配方法报告、随机化和盲法方面提高研究质量将加速试验所需的进展。
Objective: Triptolide (TL), a natural product isolated from Tripterygium wilfordii Hook F (TwHF), shows potent anticancer effects in vitro and in vivo. We aimed to summary the biochemical mechanisms through which TL has been shown to induce apoptosis, autophagy and inhibit angiogenesis in pancreatic cancer (PC). Methods: We undertook a systematic review of preclinical evidence. We searched electronic databases. The potential mechanisms and the underlying signaling pathways have been accumulated as well. Results: We screened 116 abstracts for eligibility and included 17 preclinical studies in the analysis. Details of the animals and cell lines were provided in 16 studies (94.1%). Six studies (75.0%) randomly assigned animals to treatment or control groups and only 1 study (12.5%) reported on blinding. The majority of the TL's research field has focused on its pro-apoptotic effects through downregulation of inhibitory pathways and upregulation of apoptotic pathways. The studies have shown that TL is effective both in vitro and in vivo against PC cells. Conclusion: This study provides a systematic summary of TL's anti-pancreatic cancer profile and the underlying mechanisms of with special emphasis on the apoptosis, autophagy, angiogenesis and related molecular pathways. Improved study quality in terms of treatment allocation methods reporting, randomization and blinding will accelerate needed progress toward trials.
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TRAIL 和雷公藤甲素：诱导胰腺癌细胞凋亡的有效组合。
影响因子：
3.2
作者：
Borja-Cacho, Daniel;Yokoyama, Yumi;Chugh, Rohit K.;Mujumdar, Nameeta R.;Dudeja, Vikas;Clawson, Kimberly A.;Dawra, Rajinder K.;Saluja, Ashok K.;Vickers, Selwyn M.
通讯作者：
Vickers, Selwyn M.
CD133+肿瘤在胰腺癌的合成鼠模型中启动细胞对Minnelide有反应。
DOI：
10.1158/1078-0432.ccr-13-2947
发表时间：
2014-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Banerjee S;Nomura A;Sangwan V;Chugh R;Dudeja V;Vickers SM;Saluja A
通讯作者：
Saluja A
影响因子：
37.3
作者：
Chen Z;Sangwan V;Banerjee S;Mackenzie T;Dudeja V;Li X;Wang H;Vickers SM;Saluja AK
通讯作者：
Saluja AK
影响因子：
5.7
作者：
MacKenzie TN;Mujumdar N;Banerjee S;Sangwan V;Sarver A;Vickers S;Subramanian S;Saluja AK
通讯作者：
Saluja AK
影响因子：
29.4
作者：
Mujumdar N;Mackenzie TN;Dudeja V;Chugh R;Antonoff MB;Borja-Cacho D;Sangwan V;Dawra R;Vickers SM;Saluja AK
通讯作者：
Saluja AK