Sesquiterpene esters from the fruits of Celastrus orbiculatus
Sesquiterpene esters from the fruits of Celastrus orbiculatus
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DOI：
10.1248/cpb.52.1134
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发表时间：
2004-09-01
影响因子：
1.7
通讯作者：
Wang, JH
中科院分区：
文献类型：
--
作者：
Guo, YQ;Li, X;Wang, JH
三种新的 β-二氢沉香呋喃倍半萜酯：6α-乙酰氧基-9β-苯甲酰氧基-1β-肉桂酰氧基-8β-丁酰氧基-β-二氢沉香呋喃 (1)、6α-乙酰氧基-9β-苯甲酰氧基-1β-肉桂酰氧基-8β-(2-甲基丁酰氧基)-β-二氢沉香呋喃 (2) 和从南蛇藤THUNB 的果实中分离出6α-乙酰氧基-1β,8β-二苯甲酰氧基-9β-羟基-β-二氢沉香呋喃(6) 以及三种已知化合物(3-5)。基于光谱方法阐明了它们的结构。化合物 4 在抑制小鼠巨噬细胞 RAW264.7 细胞中 LPS 诱导的一氧化氮产生方面表现出中等活性，IC50 值为 43.7 μM。
Three new beta-dihydroagarofuran sesquiterpene esters, 6alpha-acetoxy-9beta-benzoyloxy-1beta-cinnamoyloxy-8beta-butanoyloxy-beta-dihydroagarofuran (1), 6alpha-acetoxy-9beta-benzoyloxy-1beta-cinnamoyloxy-8beta-(2-methylbutanoyloxy)-beta-dihydroagarofuran (2), and 6alpha-acetoxy-1beta,8beta-dibenzoyloxy-9beta-hydroxy-beta-dihydroagarofuran (6), together with three known compounds (3-5) were isolated from the fruits of Celastrus orbiculatus THUNB. Their structures were elucidated on the basis of spectroscopic methods. Compound 4 showed moderate activity in inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells with an IC50 value of 43.7 muM.