MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients.
MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients.
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DOI：
10.1016/j.biopha.2021.112067
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Becari C
中科院分区：
文献类型：
--
作者：
D Avila-Mesquita C;Couto AES;Campos LCB;Vasconcelos TF;Michelon-Barbosa J;Corsi CAC;Mestriner F;Petroski-Moraes BC;Garbellini-Diab MJ;Couto DMS;Jordani MC;Ferro D;Sbragia L;Joviliano EE;Evora PR;Carvalho Santana R;Martins-Filho OA;Polonis K;Menegueti MG;Ribeiro MS;Auxiliadora-Martins M;Becari C
呼吸道症状是COVID-19的表现之一，而金属蛋白酶（MMPs）在肺生理学中具有重要作用。我们试图描述重度COVID-19患者血浆基质金属蛋白酶-2和9（MMP-2和MMP-9）水平的特征，并研究血浆MMP-2和MMP-9水平与临床结局和死亡率之间的相关性。采用酶谱法测定了在ICU接受治疗的COVID-19患者（COVID-19组）和对照患者血浆中的MMP-2和MMP-9水平。研究组在年龄、性别、高血压、糖尿病、BMI和肥胖方面相匹配。与对照组相比，COVID-19组的MMP-2水平较低，MMP-9水平较高（p < 0.0001）。COVID-19患者的MMP-9水平不受高血压或肥胖等合并症的影响。MMP-2水平受高血压的影响（p < 0.05），但不受肥胖状态的影响。值得注意的是，与非高血压COVID-19组相比，高血压COVID-19患者具有更高的MMP-2水平，尽管仍低于对照组（p < 0.05）。在COVID-19患者中，未发现MMP-2和MMP-9血浆水平与皮质类固醇治疗或急性肾损伤之间的相关性。生存分析显示，COVID-19死亡率与MMP-2和MMP-9水平升高相关。年龄、高血压、BMI、MMP-2和MMP-9是住院期间死亡率的更好预测因子，而入院时的SAPS 3和SOFA评分则是更好的预测因子。总之，MMP-2和MMP-9水平与COVID-19之间存在显著相关性。值得注意的是，MMP-2和MMP-9水平可预测院内死亡风险，提示可能的病理生理和预后作用。
Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography. The study groups were matched for age, sex, hypertension, diabetes, BMI, and obesity profile. MMP-2 levels were lower and MMP-9 levels were higher in a COVID-19 group (p < 0.0001) compared to Controls. MMP-9 levels in COVID-19 patients were not affected by comorbidity such as hypertension or obesity. MMP-2 levels were affected by hypertension (p < 0.05), but unaffected by obesity status. Notably, hypertensive COVID-19 patients had higher MMP-2 levels compared to the non-hypertensive COVID-19 group, albeit still lower than Controls (p < 0.05). No association between MMP-2 and MMP-9 plasmatic levels and corticosteroid treatment or acute kidney injury was found in COVID-19 patients. The survival analysis showed that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP-2 and MMP-9 were better predictors of mortality during hospitalization than SAPS3 and SOFA scores at hospital admission. In conclusion, a significant association between MMP-2 and MMP-9 levels and COVID-19 was found. Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles.
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DOI：
10.1007/978-1-4939-7111-4_6
发表时间：
2017-01-01
期刊：
ZYMOGRAPHY
影响因子：
--
作者：
Bencsik, Peter;Bartekova, Monika;Ferdinandy, Peter
通讯作者：
Ferdinandy, Peter
DOI：
10.1097/mpg.0000000000000668
发表时间：
2015-08
影响因子：
2.9
作者：
Beppu L;Yang T;Luk M;Newbury RO;Palmquist J;Dohil R;Kurten RC;Broide DH;Aceves SS
通讯作者：
Aceves SS
影响因子：
2.2
作者：
Karakurt, Hamza Umut;Pir, Pinar
通讯作者：
Pir, Pinar
影响因子：
64.8
作者：
Imai Y;Kuba K;Rao S;Huan Y;Guo F;Guan B;Yang P;Sarao R;Wada T;Leong-Poi H;Crackower MA;Fukamizu A;Hui CC;Hein L;Uhlig S;Slutsky AS;Jiang C;Penninger JM
通讯作者：
Penninger JM
影响因子：
6.1
作者：
Hazra, Suvojit;Chaudhuri, Alok Ghosh;Chakrabarti, Nilkanta
通讯作者：
Chakrabarti, Nilkanta