Regulation of mammalian tooth cusp patterning by ectodin
Regulation of mammalian tooth cusp patterning by ectodin
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DOI：
10.1126/science.1116848
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发表时间：
2005-09-23
期刊：
影响因子：
56.9
通讯作者：
Itoh, N
中科院分区：
文献类型：
--
作者：
Kassai, Y;Munne, P;Itoh, N
哺乳动物牙冠有精确的功能要求，但在萌出后不能进行实质性的重塑。在发育中的牙齿中，上皮细胞、信号中心、釉质结在未来牙尖位置形成，并且是区分物种的牙尖模式的第一个迹象。我们报告，ectodin，一种分泌的骨形态发生蛋白（BMP）抑制剂，表达为“阴性”！老鼠牙釉质结图片。此外，我们发现，ectodin缺陷小鼠有扩大的釉质结，高度改变的牙尖模式，和额外的牙齿。与正常牙齿不同，过量的BMP会加速缺乏ectodin的牙齿的图案化。我们建议，ectodin是至关重要的强大的空间描绘的釉质结和牙尖。
Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial, signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative'! image of mouse enamel knots. Furthermore, we show that ectodin-deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin-deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps.