Ginseng pharmacology - Multiple constituents and multiple actions
Ginseng pharmacology - Multiple constituents and multiple actions
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DOI：
10.1016/s0006-2952(99)00212-9
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发表时间：
1999-12-01
影响因子：
5.8
通讯作者：
Yuan, CS
中科院分区：
文献类型：
--
作者：
Attele, AS;Wu, JA;Yuan, CS
人参在远东是一种非常有价值的草药，在过去十年中在西方也很受欢迎。关于人参及其成分的有益作用有大量文献。人参的主要活性成分是人参皂苷，这是一组不同的甾体皂苷，它能够靶向多种组织，产生一系列药理反应。然而，人参皂苷活性的许多机制仍然未知。由于人参皂苷和人参的其他成分产生的作用彼此不同，并且单一的人参皂苷在同一组织中引发多种作用，因此人参的整体药理学是复杂的。人参皂苷独立靶向质膜多受体系统以及激活细胞内类固醇受体的能力可以解释一些药理作用。本评论旨在回顾人参和人参皂苷的选定效果并描述其可能的作用方式。讨论了人参皂苷的结构变异性、与类固醇的结构和功能关系以及潜在的作用靶标。生物化学制药 58;11:1685-1693, 1999。(C) 1999 Elsevier Science Inc.
Ginseng is a highly valued herb in the Far East and has gained popularity in the West during the last decade. There is extensive literature on the beneficial effects of ginseng and its constituents. The major active components of ginseng are ginsenosides, a diverse group of steroidal saponins, which demonstrate the ability to target a myriad of tissues, producing an array of pharmacological responses. However, many mechanisms of ginsenoside activity still remain unknown. Since ginsenosides and other constituents of ginseng produce effects that are different from one another, and a single ginsenoside initiates multiple actions in the same tissue, the overall pharmacology of ginseng is complex. The ability of ginsenosides to independently target multireceptor systems at the plasma membrane, as well as to activate intracellular steroid receptors, may explain some pharmacological effects. This commentary aims to review selected effects of ginseng and ginsenosides and describe their possible modes of action. Structural variability of ginsenosides, structural and functional relationship to steroids, and potential targets of action are discussed. BIOCHEM PHARMACOL 58;11:1685-1693, 1999. (C) 1999 Elsevier Science Inc.