Platelet infiltration predicts survival in postsurgical colorectal cancer patients
Platelet infiltration predicts survival in postsurgical colorectal cancer patients
复制标题
血小板浸润可预测结直肠癌术后患者的生存率
DOI：
10.1002/ijc.33816
复制
发表时间：
2021-10-19
影响因子：
6.4
通讯作者：
Zhao, Jingkun
中科院分区：
文献类型：
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作者：
Miao, Yiming;Xu, Zifeng;Zhao, Jingkun
在几种肿瘤类型中，血小板促进肿瘤生长和转移。最近的研究发现，血小板可以渗入和渗透到肿瘤间质中，并与肿瘤微环境相互作用。血小板在结直肠癌(CRC)中的预后作用仍存在争议。对肿瘤患者进行全癌生存分析，以找出肿瘤患者中血小板渗入的潜在预后价值。建立了生存分析和诺模图预后模型，以进一步验证本中心的数据结果。通过CD42b免疫组织化学染色确定患者预后与肿瘤浸润性血小板(TIPS)之间的相关性。一致性指数(C-index)和校正曲线决定了诺模图的预测准确性和判别能力。泛癌生存分析显示，在包括结直肠癌在内的几种癌症患者中，血小板渗透可能导致预后不良。在初始队列和验证队列中，血小板渗透与总生存期(OS)和无病生存期(DFS)相关。诺模图预测OS和DFS的C指数分别为0.774和0.769，高于单独使用TNM分期系统。我们的研究发现，血小板渗入对结直肠癌患者术后存活率有潜在的预后价值。建议的诺模图导致了对术后CRC患者更准确的预后预测。
Platelets promote tumor growth and metastasis in several tumor types. Recent research has found platelets can extravasate and infiltrate into the tumor stroma and interact with the tumor microenvironment. The prognostic role of platelet infiltration in colorectal cancer (CRC) remains controversial. A pan‐cancer survival analysis was performed to find the potential prognostic value of platelet infiltration in patients with cancer. A survival analysis and a nomogram prognostic model were established to further confirm the results with data from our center. The correlations between patient outcomes and tumor‐infiltrating platelets (TIPs) were identified by immunohistochemical staining for CD42b. The prognostic accuracy and discriminative ability of the nomogram were determined by the concordance index (C‐index) and a calibration curve. The pan‐cancer survival analysis showed platelet infiltration can lead to a poor prognosis in patients with several types of cancers, including CRC. Platelet infiltration was associated with overall survival (OS) and disease‐free survival (DFS) in both primary and validation cohorts. The C‐index values of the nomogram for predicting OS and DFS were 0.774 and 0.769, respectively, which were higher than that of the TNM staging system alone. Our study found platelet infiltration has a potential prognostic value regarding postsurgical survival in CRC patients. The proposed nomogram resulted in a more accurate prognostic prediction for postsurgical CRC patients.