SPIRAL GANGLION NEURON LOSS FOLLOWING ORGAN OF CORTI LOSS - A QUANTITATIVE STUDY
SPIRAL GANGLION NEURON LOSS FOLLOWING ORGAN OF CORTI LOSS - A QUANTITATIVE STUDY
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DOI：
10.1016/0006-8993(81)90028-7
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发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
WEBSTER, DB
中科院分区：
文献类型：
--
作者：
WEBSTER, M;WEBSTER, DB
在2.5个月和13~15个月测量螺旋神经节神经元的堆积密度。老年豚鼠，药物耳聋或声损伤后不同时间的豚鼠和不同年龄的华尔兹豚鼠。用方差分析和邓肯-S新的多重范围检验确定治疗/存活组之间的显著差异。青年和老年正常耳螺旋神经节神经元的堆积密度无明显差异。药物耳聋豚鼠在治疗后2周出现明显的神经元丢失，在治疗后2个月进一步显著丢失。在4到8个月之间有轻微的损失。神经元数量在15个月内保持稳定，约为正常的13%。1个月时，声伤耳在下2个转弯时出现第1个显著缺失。长期(12-14个月。暴露后)，创伤的耳朵是高度可变的。华尔兹舞者在4到8个月之间失去了大约50%的正常神经元；他们在2个月时表现出意外的高于正常密度，讨论了可能的解释。由于各种原因造成的Corti器官的丧失会导致螺旋神经节神经元的缓慢但渐进性的丧失，其时间进程因耳蜗性损伤的类型而异。
The packing density of spiral ganglion neurons was measured in 2.5 and 13-15 mo. old guinea pigs, in guinea pigs at various times after drug-deafening or acoustic trauma and in Waltzing guinea pigs of various ages. Analysis of variance and Duncan''s new multiple range tests were used to determine significant differences between treatment/survival groups. Spiral ganglion neurons in young and old normal ears did not have significantly different packing densities. Drug-deaf guinea pigs showed a significant loss of neurons by 2 wk following treatment, a further significant loss by 2 mo. and a marginally significant loss between 4 and 8 mo. The neuronal population was then stable through 15 mo., at about 13% of normal. Acoustic trauma ears showed the 1st significant loss in the lower 2nd turn at 1 mo. Long-term (12-14 mo. post-exposure) trauma ears were highly variable. Waltzers lost about 50% of their normal neuronal population between 4 and 8 mo.; they showed an unexpected greater than normal density at 2 mo., possible explanations of which are discussed. Loss of the organ of Corti from various causes results in a slow but progressive loss of spiral ganglion neurons, the time course of which varies with the type of cochlear insult.