Biosensors for biomarkers in medical diagnostics
Biosensors for biomarkers in medical diagnostics
复制标题
DOI：
10.1080/13547500802645905
复制
发表时间：
2008-01-01
期刊：
影响因子：
2.6
通讯作者：
Tombelli, S.
中科院分区：
文献类型：
--
作者：
Mascini, M.;Tombelli, S.
目前，大多数生物标志物检测都是在使用大型自动化分析仪的集中专用实验室进行的，这增加了等待时间和成本。非常需要更小、更快和更便宜的设备来取代这些耗时的实验室分析，并使分析结果在患者床边可用（即时诊断）。创新的生物传感器为基础的战略可以让生物标志物进行可靠的测试，在分散的设置，虽然仍然存在一些挑战和限制，需要改进，在生物传感器的设计和应用，以适当的解释确定和量化的生物标志物。生物传感器的发展可能是最有前途的方法来解决一些问题，越来越多的需要开发高灵敏度，快速和经济的分析方法在医疗诊断。在这篇综述中，将考虑生物传感器及其在医学诊断中的应用，同时考虑到几个关键特征。
At present, most biomarker testing is taking place at centralised dedicated laboratories using large, automated analysers, increasing waiting time and costs. Smaller, faster and cheaper devices are highly desired for replacing these time-consuming laboratory analyses and for making analytical results available at the patient's bedside (point-of-care diagnostics). Innovative biosensor-based strategies could allow biomarkers to be tested reliably in a decentralised setting, although several challenges and limitations remain, which need to be improved, in the design and application of biosensors for the appropriate interpretation of the identified and quantified biomarkers. The development of biosensors is probably one of the most promising ways to solve some of the problems concerning the increasing need to develop highly sensitive, fast and economic methods of analysis in medical diagnostics. In this review, some consideration will be given to biosensors and their application in medical diagnostics, taking into account several crucial features.