Prediction of preeclampsia by analysis of cell-free messenger RNA in maternal plasma
Prediction of preeclampsia by analysis of cell-free messenger RNA in maternal plasma
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DOI：
10.1016/j.ajog.2008.11.035
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发表时间：
2009-04-01
影响因子：
9.8
通讯作者：
Okai, Takashi
中科院分区：
文献类型：
--
作者：
Purwosunu, Yuditiya;Sekizawa, Akihiko;Okai, Takashi
目的：本研究的目的是预测先兆子痫的发生在一系列的患者在孕周15-20周，与使用一个面板的信使RNA markers.Study设计：数据从62例先兆子痫谁是无症状的血液检测和310对照组进行了分析。结果：单因素分析显示血管内皮生长因子受体1的检出率最高，胎盘特异性受体1的检出率最低。对照受试者的先兆子痫平均估计评分为9.4，发生先兆子痫的受试者为72.5。以先兆子痫的估计评分作为检验变量得到的受试者工作特征曲线在5%假阳性率下的检出率为84%（95%CI，71.8-91.5），曲线下面积为0.927（P <0.001）。同样，检测率和评分为每个患者的分类为先兆子痫的severity.CONCLUSION：一个面板的信使RNA是能够检测受试者谁将经历先兆子痫。
OBJECTIVE: The purpose of this study was to predict the occurrence of preeclampsia in a series of patients at gestational week 15-20 weeks, with the use of a panel of messenger RNA markers.STUDY DESIGN: Data from 62 patients with preeclampsia who were asymptomatic at the time of blood testing and 310 control subjects were analyzed. Multivariable analysis was performed with discriminant analysis.RESULTS: Univariable analysis identified vascular endothelial growth factor receptor 1 as the marker with the highest detection rate; placenta-specific 1 with the lowest. Mean estimated score for preeclampsia was 9.4 for control subjects and 72.5 for subjects who experienced preeclampsia. A receiver operating characteristic curve that was obtained with the estimated score for preeclampsia as a test variable yielded a detection rate of 84% (95% CI, 71.8-91.5) at a 5% false-positive rate with an area under the curve of 0.927 (P < .001). Again, detection rate and score for each patient for classification as preeclamptic correlated with severity.CONCLUSION: A panel of messenger RNA is able to detect subjects who will experience preeclampsia.