Host immunity to Cryptococcus neoformans.
Host immunity to Cryptococcus neoformans.
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DOI：
10.2217/fmb.14.132
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发表时间：
2015
影响因子：
3.1
通讯作者：
Pirofski LA
中科院分区：
文献类型：
--
作者：
Rohatgi S;Pirofski LA
隐球菌病是由真菌隐球菌属引起的。隐球菌病，主要是脑膜脑炎，与艾滋病毒大流行一起出现，主要影响T细胞严重缺乏的艾滋病毒感染患者。在使用中，联合抗逆转录病毒疗法显著降低了发病率和患病风险，但隐球菌病继续困扰着那些无法获得治疗的人，特别是在撒哈拉以南非洲和亚洲。然而，隐球菌病也发生在实体器官移植接受者和有其他免疫缺陷的患者以及那些没有已知免疫缺陷的患者中。本文综述了对新生隐球菌属的先天免疫和获得性免疫反应，重点介绍了B细胞、天然免疫球蛋白M和Fcγ受体基因多态性在隐球菌病耐药性中的作用。
Cryptococcosis is caused by the fungal genus Cryptococcus. Cryptococcosis, predominantly meningoencephalitis, emerged with the HIV pandemic, primarily afflicting HIV-infected patients with profound T-cell deficiency. Where in use, combination antiretroviral therapy has markedly reduced the incidence of and risk for disease, but cryptococcosis continues to afflict those without access to therapy, particularly in sub-Saharan Africa and Asia. However, cryptococcosis also occurs in solid organ transplant recipients and patients with other immunodeficiencies as well as those with no known immunodeficiency. This article reviews innate and adaptive immune responses to C. neoformans, with an emphasis on recent studies on the role of B cells, natural IgM and Fc gamma receptor polymorphisms in resistance to cryptococcosis.