Two-year changes in lipids and lipoproteins associated with the maintenance of a 5% to 10% reduction in initial weight: Some findings and some questions
Two-year changes in lipids and lipoproteins associated with the maintenance of a 5% to 10% reduction in initial weight: Some findings and some questions
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DOI：
10.1002/j.1550-8528.1999.tb00699.x
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发表时间：
1999-03-01
期刊：
影响因子：
--
通讯作者：
Foster, GD
中科院分区：
文献类型：
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作者：
Wadden, TA;Anderson, DA;Foster, GD
目的：本研究评估初始体重减少 5% 至 10% 是否与短期（即 8 周）观察到的脂质和脂蛋白的长期（即 100 周）有利变化相关。 研究方法和程序：这是对 25 名肥胖女性的前瞻性评估，每名女性在 48 周的治疗期间体重减轻大于或等于初始体重的 5%，并维持体重体重减轻 1 年随访（第 100 周）时达到这一程度。在基线以及第 8、24、48 和 100 周时获取脂质和脂蛋白。所有参与者的基线总胆固醇大于或等于 5.17 mmol/L (200 mg/dL)。结果：前 8 周结束时，体重平均下降 11.7+/-2.8%，总胆固醇 20.6+/-7.5%，低密度脂蛋白 (LDL) 胆固醇 23.0+/-18.1%，甘油三酯 26.0+/-20.1%。第 48 周时，体重已降至基线以下 20.1+/-7.0%，但总胆固醇和 LDL 胆固醇仅分别低于基线 11.5+/-10.4% 和 12.0+/-14.0%。后者的减少是显着的（p
Objective: This study assessed whether a 5% to 10% reduction in initial weight would be associated with as favorable long-term (i.e., 100 weeks) changes in lipids and lipoproteins, as have been observed on a short-term basis (i.e., 8 weeks).Research Methods and Procedures: This was a prospective evaluation of 25 obese women, each of whom had lost greater than or equal to 5% of initial weight during 48 weeks of treatment and had maintained a weight loss of this magnitude at 1-year follow-up (week 100). Lipids and lipoproteins were obtained at baseline and at weeks 8, 24, 48, and 100. All participants had a baseline total cholesterol greater than or equal to 5.17 mmol/L (200 mg/dL).Results: At the end of the first 8 weeks, weight fell an average of 11.7+/-2.8%, total cholesterol 20.6+/-7.5%, low-density-lipoprotein (LDL) cholesterol 23.0+/-18.1%, and triglycerides 26.0+/-20.1%. At week 48, weight had fallen to 20.1+/-7.0% below baseline, but total cholesterol and LDL cholesterol were reduced only 11.5+/-10.4% and 12.0+/-14.0% below baseline, respectively. These latter reductions were significantly (p