Cell-Size-Dependent Control of Organelle Sizes During Development
Cell-Size-Dependent Control of Organelle Sizes During Development
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DOI：
10.1007/978-3-642-19065-0_5
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Kimura, Akatsuki
中科院分区：
文献类型：
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作者：
Hara, Yuki;Kimura, Akatsuki
在发育过程中，细胞分化成不同大小的不同类型的细胞。细胞内细胞器的大小通常与细胞的大小相关，这可能对细胞的动态平衡很重要。细胞核是细胞器的一个众所周知的例子，它的大小与细胞的大小相关。然而，这种关联的力学基础尚不清楚。有丝分裂纺锤体和收缩环的长度作为模型系统出现，以研究细胞器大小依赖于细胞大小的控制机制。提出了这些细胞器与细胞大小相关的控制机制模型。了解细胞器大小对细胞大小的依赖不仅对单个细胞器的形态发生产生影响，而且对细胞内稳态、细胞周期进程和细胞分化产生影响。
During development, cells differentiate into diverse cell types with different sizes. The size of intracellular organelles often correlates with the size of the cell, which may be important for cell homeostasis. The nucleus is a well-known example of an organelle whose size correlates with cell size. However, the mechanical basis of the correlation is unknown. The lengths of the mitotic spindle and contractile ring are emerging as model system to investigate the cell-size-dependent control mechanisms of organelle size. Mechanistic models are proposed for the cell-size-dependent control of these organelles. Understanding the cell-size dependency of organelle sizes is expected to impact not only on the morphogenesis of the individual organelle, but also on cell homeostasis, cell cycle progression, and cell differentiation.