Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole
Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole
复制标题
DOI：
10.1038/23475
复制
发表时间：
1999-08
期刊：
影响因子：
64.8
通讯作者：
L. Young;R. Nilsen;K. Waymire;G. MacGregor;T. Insel
中科院分区：
文献类型：
--
作者：
L. Young;R. Nilsen;K. Waymire;G. MacGregor;T. Insel
精氨酸加压素通过作用于大脑中的V1a受体，影响几种脊椎动物的雄性生殖和社会行为。加压素V1a受体的神经解剖学分布在不同社会组织形式的物种之间差异很大。在这里，我们表明，中央管理精氨酸加压素增加高度社会性的，一夫一妻制的草原田鼠的附属行为，但不在相对非社会性的，混杂的山地田鼠。分子分析表明，草原田鼠受体基因的基因复制和/或启动子结构的改变可能是导致加压素受体表达的物种差异的原因。我们进一步表明，转草原田鼠受体基因的小鼠具有与草原田鼠相似的受体结合的神经解剖学模式，并在注射精氨酸加压素后表现出更多的附属行为。这些数据表明，大脑中V1a受体基因的表达模式可能在功能上与雄性脊椎动物的物种典型社会行为有关。
Arginine vasopressin influences male reproductive and social behaviours in several vertebrate taxa through its actions at the V1areceptor in the brain. The neuroanatomical distribution of vasopressin V1areceptors varies greatly between species with different forms of social organization,. Here we show that centrally administered arginine vasopressin increases affiliative behaviour in the highly social, monogamous prairie vole, but not in the relatively asocial, promiscuous montane vole. Molecular analyses indicate that gene duplication and/or changes in promoter structure of the prairie vole receptor gene may contribute to the species differences in vasopressin-receptor expression. We further show that mice that are transgenic for the prairie vole receptor gene have a neuroanatomical pattern of receptor binding that is similar to that of the prairie vole, and exhibit increased affiliative behaviour after injection with arginine vasopressin. These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates.