Epidemiological significance of repeated infections with homologous and heterologous strains and species of Plasmodium.
Epidemiological significance of repeated infections with homologous and heterologous strains and species of Plasmodium.
复制标题
同源和异源疟原虫菌株和物种重复感染的流行病学意义。
DOI：
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发表时间：
1966
影响因子：
11.1
通讯作者：
G. Jeffery
中科院分区：
文献类型：
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作者：
G. Jeffery
在使用诱导疟疾治疗神经梅毒的多年经验中，可以观察已知既往有相同和不同疟原虫株和种属感染史的患者的疟疾感染过程。本报告从宿主免疫反应、临床症状、寄生虫血症、传染性和化疗措施等方面介绍了既往感染对后续感染的影响。这些研究表明，在任何情况下都不可能在患者中引起额外的感染。然而，在所有同源物种再接种，有显着的修改的感染，这是加强，如果两个曝光是相同的菌株。可变的结果（范围从没有明显的影响，相当大的修改）后，重新接种的患者与异源物种的Plasmodium.The免疫荧光方法的使用可能会提供一个更清晰的理解的机制，部分免疫，因为它会影响再感染。在流行地区，这种部分免疫与疾病的流行病学和化疗的关系是重要的，因为半免疫人群中的这些感染提供了社区再感染的持续和不明显的来源。
During many years of experience with the use of induced malaria for the therapy of neurosyphilis, it has been possible to observe the course of malarial infections in patients with known previous history of infection by the same and different strains and species of Plasmodium. This report presents the effect of prior infection on subsequent infection in regard to immune response of the host, clinical symptoms, parasitaemia, transmissibility and chemotherapeutic measures. These studies have shown that in no case was it impossible to induce additional infections in patients. However, in all homologous-species reinoculations, there were significant modifications of the infections, which were enhanced if both exposures were to the same strain. Variable results (ranging from no apparent effect to a fairly substantial modification) were seen after reinoculation of patients with a heterologous species of Plasmodium.The use of immunofluorescent methods may provide a clearer understanding of the mechanism of partial immunity as it affects reinfection. The relationship of this partial immunity to the epidemiology and chemotherapy of the disease in endemic areas is of importance, in that these infections in semi-immune persons provide a continuing and unapparent source of reinfection of the community.