A Short History of Dapsone, or an Alternative Model of Drug Development
A Short History of Dapsone, or an Alternative Model of Drug Development
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DOI：
10.1093/jhmas/jrq068
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发表时间：
2011-10-01
影响因子：
0.5
通讯作者：
Barr, Justin
中科院分区：
文献类型：
--
作者：
Barr, Justin
从1936年到1996年，药物氨苯砜治疗了各种疾病，包括结核病，麻风病，疟疾和艾滋病相关的肺炎。本文探讨了氨苯砜如何从一种疾病的治疗转变为一种完全不同的疾病的治疗。这种临床上的再造过程代表了药物开发的另一种模式，而历史文献主要关注实验室的成功，在很大程度上忽略了这一点。本文的核心讨论了氨苯砜作为抗疟药在越南战争中通过由罗伯特J。T。乔伊是一名医生和军官。作为一个案例研究，它提供了一个新的角度对临床实验室的方法，其他学者在民用背景下解决。通过军事棱镜观察随机临床试验（RCT）将展示作战环境与武装部队的编组如何影响RCT的标准方法。
From 1936 until 1996, the drug dapsone treated a diverse array of diseases, including tuberculosis, leprosy, malaria, and AIDS-related pneumonia. This article explores how dapsone transformed from a cure for one disease into a treatment for a totally different malady. This process of reinvention in the clinic represents an alternative model of drug development that the historical literature, focused on success in the laboratory, has largely ignored. The core of the paper discusses the reinvention of dapsone as an antimalarial in the Vietnam War through trials led by Robert J. T. Joy, a physician and military officer. As a case study, it offers a fresh perspective on the clinic-as-laboratory approach that other scholars have addressed in a civilian context. Viewing the randomized clinical trial (RCT) through a military prism will demonstrate how a combat environment combined with the regimentation of the armed forces affected the standard methodology of the RCT.