Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain.
Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain.
复制标题
线粒体和自噬调节健康和脑损伤的成年神经发生。
DOI：
10.3390/ijms22073342
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发表时间：
2021-03-24
影响因子：
5.6
通讯作者：
Büeler H
中科院分区：
文献类型：
--
作者：
Büeler H
成人神经发生是一个高度调控的过程，在此过程中，神经干细胞在成人大脑的两个离散区域产生新的神经元：侧脑室的室下区和海马齿状回的亚颗粒区。成人海马神经发生缺陷与自然衰老过程中的认知能力下降和功能障碍、神经退行性疾病以及心理应激性情绪障碍有关。了解调节成人神经发生的机制和途径对于改善这些疾病的预防措施和治疗至关重要。越来越多的证据表明，线粒体直接调节成人神经发生的各个步骤和阶段。本文综述了线粒体代谢、动力学和活性氧如何控制成体神经干细胞功能及其向新生神经元分化的几个方面的最新发现。它还讨论了自噬对成人神经发生的重要性，以及线粒体和自噬功能障碍如何通过损害成人神经发生而导致认知缺陷和应激性情绪障碍。最后，我提出了针对线粒体功能的可能方法，作为基于干细胞的干预和治疗认知和情绪障碍的策略。
Adult neurogenesis is a highly regulated process during which new neurons are generated from neural stem cells in two discrete regions of the adult brain: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. Defects of adult hippocampal neurogenesis have been linked to cognitive decline and dysfunction during natural aging and in neurodegenerative diseases, as well as psychological stress-induced mood disorders. Understanding the mechanisms and pathways that regulate adult neurogenesis is crucial to improving preventative measures and therapies for these conditions. Accumulating evidence shows that mitochondria directly regulate various steps and phases of adult neurogenesis. This review summarizes recent findings on how mitochondrial metabolism, dynamics, and reactive oxygen species control several aspects of adult neural stem cell function and their differentiation to newborn neurons. It also discusses the importance of autophagy for adult neurogenesis, and how mitochondrial and autophagic dysfunction may contribute to cognitive defects and stress-induced mood disorders by compromising adult neurogenesis. Finally, I suggest possible ways to target mitochondrial function as a strategy for stem cell-based interventions and treatments for cognitive and mood disorders.
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影响因子：
2.7
作者：
Agnihotri, Sandeep K.;Sun, Liuke;Bueler, Hansruedi
通讯作者：
Bueler, Hansruedi
影响因子：
3.7
作者：
Akundi RS;Huang Z;Eason J;Pandya JD;Zhi L;Cass WA;Sullivan PG;Büeler H
通讯作者：
Büeler H
影响因子：
16.2
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影响因子：
4
作者：
Chao, Fenglei;Jiang, Lin;Tang, Yong
通讯作者：
Tang, Yong
影响因子：
3.1
作者：
Ali, Amira A. H.;Schwarz-Herzke, Beryl;von Gall, Charlotte
通讯作者：
von Gall, Charlotte