Model-based control of cardiac alternans in Purkinje fibers
Model-based control of cardiac alternans in Purkinje fibers
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DOI：
10.1103/physreve.84.041927
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发表时间：
2011-10-21
影响因子：
2.4
通讯作者：
Fenton, Flavio H.
中科院分区：
文献类型：
--
作者：
Garzon, Alejandro;Grigoriev, Roman O.;Fenton, Flavio H.
本文介绍了一种系统的方法来抑制心脏交替在模拟浦肯野纤维局部电流注入。我们调查的可控性和可观性的周期性起搏的诺布尔模型的记录和控制电极的不同位置。特别是，我们表明，可控性的损失导致失败的控制方法介绍了Echebarria和Karma [混沌12，923（2002）]较长的纤维长度。此外，我们解释了如何记录和控制电极的最佳位置和反馈电流的定时可以选择，占线性和非线性效应，有效地增加了一倍的纤维，可以控制与以前的方法的长度。
This paper describes a systematic approach to suppressing cardiac alternans in simulated Purkinje fibers using localized current injections. We investigate the controllability and observability of the periodically paced Noble model for different locations of the recording and control electrodes. In particular, we show that the loss of controllability causes the failure of the control approach introduced by Echebarria and Karma [Chaos 12, 923 (2002)] for longer fiber lengths. Furthermore, we explain how the optimal locations for the recording and control electrodes and the timing of the feedback current can be selected, accounting for both linear and nonlinear effects, effectively doubling the length of fibers that can be controlled with previous methods.