Effects of the instrument response function and the gate width in time-domain diffuse correlation spectroscopy: model and validations
Effects of the instrument response function and the gate width in time-domain diffuse correlation spectroscopy: model and validations
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DOI：
10.1117/1.nph.6.3.035001
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发表时间：
2019-07-01
期刊：
影响因子：
5.3
通讯作者：
Pifferi, Antonio
中科院分区：
文献类型：
--
作者：
Colombo, Lorenzo;Pagliazzi, Marco;Pifferi, Antonio
时域漫射相关光谱（TD-DCS）是一种新兴的无创光学技术，具有深入分析血流（BF）和光学系数（减少散射和吸收）的潜力。在这里，我们在一个现实的TD-DCS实验中研究了有限时间分辨率和栅极宽度的影响。我们提供了一个基于仪器响应函数从门控强度自相关中检索BF的模型，该模型允许使用宽时间门。这反过来又实现了更高的信噪比，这对体内应用至关重要。在数值模拟中，该模型的使用将估计的后门BF误差从34%降低到3%。模拟也进行了广泛的光学性质和源探测器的分离。在均匀模体实验中，后门的BF指数与未门的BF指数的差异从37%减小到2%。这项工作不仅为数据分析提供了工具，而且还提供了物理见解，这对于研究和优化系统性能非常有用。(C)作者。根据知识共享署名4.0未移植许可协议，由SPIE发布。
Time-domain diffuse correlation spectroscopy (TD-DCS) is an emerging noninvasive optical technique with the potential to resolve blood flow (BF) and optical coefficients (reduced scattering and absorption) in depth. Here, we study the effects of finite temporal resolution and gate width in a realistic TD-DCS experiment. We provide a model for retrieving the BF from gated intensity autocorrelations based on the instrument response function, which allows for the use of broad time gates. This, in turn, enables a higher signal-to-noise ratio that is critical for in vivo applications. In numerical simulations, the use of the proposed model reduces the error in the estimated late gate BF from 34% to 3%. Simulations are also performed for a wide set of optical properties and source-detector separations. In a homogeneous phantom experiment, the discrepancy between later gates BF index and ungated BF index is reduced from 37% to 2%. This work not only provides a tool for data analysis but also physical insights, which can be useful for studying and optimizing the system performance. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.