Composites comprising cholesterol and carboxymethyl cellulose.
Composites comprising cholesterol and carboxymethyl cellulose.
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DOI：
10.1016/j.colsurfb.2007.08.014
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发表时间：
2008-02
期刊：
影响因子：
--
通讯作者：
V. Uskoković
中科院分区：
文献类型：
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作者：
V. Uskoković
其中胆固醇是人体内主要的脂肪物质之一，而羧甲基纤维素是纤维素的水溶性衍生物，纤维素是最丰富的膳食纤维。一方面，体内胆固醇沉淀是动脉粥样硬化的主要原因，而另一方面，膳食纤维因其能够清除沉积在肠道通道上的脂肪斑块并防止其在生物体内其他关键区域积聚而闻名。在这项工作中，报道了一种从1-己醇/水双相混合物制备包含胆固醇和羧甲基纤维素的复合材料的方法。在给定的合成条件下，复合成分之间相互作用的特异性抑制了固体胆固醇采用典型的板状或针状形态的趋势。相反，控制聚合物相的触变行为会导致形成起泡的多层胆甾醇薄膜。鉴于涉及胆固醇晶体生物沉淀的主要疾病，这些发现可被认为指向潜在化疗和/或营养意义的相互作用特异性。作为所制备材料表征的一部分，进行了扫描电子显微镜、热分析和衍射分析。
Whereby cholesterol presents one of the major fatty substances in human body, carboxymethyl cellulose is a water-soluble derivative of cellulose, the most abundant dietary fiber. Whereas on one hand in vivo precipitation of cholesterol is the major cause of atherosclerosis, dietary fibers are on the other hand known for their ability to clean the fatty plaque deposited on intestinal pathways, and prevent its build-up in other critical areas within the organism. In this work, a method for the preparation of a composite material comprising cholesterol and carboxymethyl cellulose from 1-hexanol/water biphase mixtures is reported. Specificity of the interaction between the composite components in the given conditions of synthesis inhibits the tendency of solid cholesterol to adopt typical plate- or needle-shaped morphologies. Instead, control of the thixotropic behavior of the constituent polymer phase leads to the formation of bubbling, multi-layered cholesteric films. In view of the major illnesses that involve biological precipitation of cholesterol crystals, these findings may be considered as pointing towards the interactional specificity of potential chemotherapeutic and/or nutritional significance. Scanning electron microscopy, thermal and diffractometric analyses were performed as parts of the characterization of the prepared material.