Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists
Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists
复制标题
DOI：
10.1016/s0091-3057(02)00748-7
复制
发表时间：
2002-06-01
影响因子：
3.6
通讯作者：
Nowrouzi, M
中科院分区：
文献类型：
--
作者：
Farzin, D;Asghari, L;Nowrouzi, M
采用两种不同的伤害性刺激：热刺激(热板刺激)和化学刺激(醋酸诱导的小鼠扭腹法)，观察了不同组胺受体激动剂和拮抗剂对小鼠伤害性阈值的影响。侧脑室(Icv)注射组胺受体激动剂组胺H(HTMT(6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)庚烷甲酰胺)(50µg/只)，在热板和扭体实验中产生超痛反应。相反，腹腔注射右氯苯丙胺(30和40 mg/kg)和苯海拉明(20和40 mg/kg)可提高两种测试中的痛阈值。组胺H-2受体激动剂迪马普利特(50和100µg/只小鼠icv)或拮抗剂雷尼替丁(50和100 l.lg/只icv)均能提高热板和扭体实验中的痛阈值。在小鼠热板实验中，组胺H-3受体激动剂imite(50 mg/kg ip)可降低痛阈值，而组胺H-3受体拮抗剂硫代巴比妥钠(10 mg/kg ip和20 mg/kg ip)则产生抗伤害效应。右氯苯丙胺(20 mg/kg ip)和硫代巴比妥钠(5 mg/kg ip)分别拮抗HTMT和免疫球蛋白的伤害性作用。结果提示，组胺能机制可能参与了伤害性刺激的调制。(C)2002 Elsevier Science Inc.保留所有权利。
The effects of different histamine receptor agonists and antagonists on the nociceptive threshold were investigated in mice by two different kinds of noxious stimuli: thermal (hot plate) and chemical (acetic acid-induced abdominal writhing). Intracerebroventricular (icv) injection of the histamine H, receptor agonist, HTMT (6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl) heptanecarboxamide) (50 mug/mouse), produced a hypernociception in the hot plate and writhing tests. Conversely, intraperitoneal (ip) injection of dexchlorpheniramine (30 and 40 mg/kg) and diphenhydramine (20 and 40 mg/kg) increased the pain threshold in both tests. The histamine H-2 receptor agonist, dimaprit (50 and 100 mug/mouse icv), or antagonist, ranitidine (50 and 100 l.Lg/mouse icv), raised the pain threshold in both hot plate and writhing tests. In the mouse hot plate test, the histamine H-3 receptor agonist, imetit (50 mg/kg ip), reduced the pain threshold, while the histamine H-3 receptor antagonist, thioperamide (10 and 20 mg/kg ip), produced an antinociception. The hypernociceptive effects of HTMT and imetit were antagonized by dexchlorpheniramine (20 mg/kg ip) and thioperamide (5 mg/kg ip), respectively. The results suggest that histaminergic mechanisms may be involved in the modulation of nociceptive stimuli. (C) 2002 Elsevier Science Inc. All rights reserved.