Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers.
Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers.
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DOI：
10.1186/1476-511x-10-138
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发表时间：
2011-08-13
影响因子：
4.5
通讯作者：
Kiso Y
中科院分区：
文献类型：
--
作者：
Kawabata T;Hirota S;Hirayama T;Adachi N;Kaneko Y;Iwama N;Kamachi K;Araki E;Kawashima H;Kiso Y
我们报道了老年人红细胞和血浆磷脂（PL）中花生四烯酸（ARA）的组成低于年轻人，尽管ARA的摄入量几乎相同。我们进一步分析了四个不同年龄和性别的研究组的数据，确定了血液ARA水平受到摄入的膳食脂肪酸种类的影响。招募了104名健康的年轻人和老年人志愿者。回顾了连续28天的饮食记录和照片记录，并分析了血浆脂质组分和红细胞PL中的脂肪酸组成。膳食脂肪酸与血脂组分之间无相关性。红细胞PL中二十碳五烯酸(EPA) +二十二碳六烯酸（DHA）摄入量与ARA组成呈显著负相关。老年人红细胞PL中ARA的组成明显低于年轻人，这是因为老年人EPA和DHA的摄入量高于年轻人。然而，在去除饮食中EPA+DHA摄入的影响后，老年人红细胞PL中的ARA成分明显低于年轻人。随着年龄的增长，身体状况的变化除了饮食中EPA和DHA的影响外，还影响了老年人红细胞ARA成分的低水平。
We reported that the compositions of arachidonic acid (ARA) in erythrocytes and plasma phospholipids (PL) in the elderly were lower than those in the young, though the ARA intake was nearly identical. We further analyzed data in four study groups with different ages and sexes, and determined that the blood ARA levels were affected by the kinds of dietary fatty acids ingested. One hundred and four healthy young and elderly volunteers were recruited. Dietary records together with photographic records from 28 consecutive days were reviewed and the fatty acid composition in plasma lipid fractions and erythrocyte PL was analyzed. No correlations for ARA between dietary fatty acids and blood lipid fractions were observed. A significant negative correlation between eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) intake and ARA composition in erythrocyte PL was observed. ARA composition in erythrocyte PL was significantly lower in elderly subjects than in young subjects, because EPA and DHA intake in elderly subjects was higher than in young subjects. However, after removing the effect of dietary EPA+DHA intake, the ARA composition in erythrocyte PL in elderly subjects was significantly lower than that in young subjects. Changes in physical conditions with aging influenced the low ARA composition of erythrocyte in elderly subjects in addition to the effects of dietary EPA and DHA.