Special Issue: Epithelial-Mesenchymal Transition 2020
Special Issue: Epithelial-Mesenchymal Transition 2020
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特刊：上皮-间质转化 2020
DOI：
10.1159/000518686
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发表时间：
2021
影响因子：
2.7
通讯作者：
Sheng Guojun
中科院分区：
文献类型：
--
作者：
Thompson Erik W.;Sheng Guojun
延续长期的传统和关系，很高兴介绍这一新的细胞组织器官特刊，该特刊是从2019年11月11日至14日在日本熊本熊本大学举行的第九届TEMTIA会议上产生的。这是在日本举行的第一次TEMTIA会议，也是一个很好的机会，可以从上皮-间质转化（EMT）丰富的国家听到更多信息，并在国际上更新。48位发言者（27名受邀代表和21名从摘要提交材料中选出的代表）和来自20个国家或地区的170名代表（澳大利亚、比利时、中国、法国、德国、香港、印度、爱尔兰、以色列、日本、韩国、马来西亚、波兰、新加坡、西班牙、瑞典、瑞士、台湾、英国和美国）欣赏了美丽、有趣、和鼓舞人心的环境，以分享丰富多样的会谈桥接发展，细胞，癌症和纤维化的主要EMT学科，因为是TEMTIA宪章（https：//temtia. org/Home/About#）.这些会议提供了一个很好的机会来分享这些不同主题的方法学发展和新知识。许多当前和热门的主题都在本特刊所载的手稿中得到了体现，我们对作者和审稿人表示感谢。Rik Thompson、Don Newgreen和Hans-Werner Denker的盛国军以虚拟采访的形式沿着记忆巷进行了一次有点怀旧的漫步，为跨学科的贡献奠定了基础，包括netrins在发育和伤口愈合中的保守作用（Michael Murray），癌症中的EMT生物标志物（克莉丝汀吉勒）--尤其是混合状态（Rik Thompson），OVOL 1和2在发展，疾病和重新编程中的驱动因素（Mohit Kumar Jolly），鸡绒毛尿囊膜（CAM）作为癌症EMT研究替代模型的新用途（Ruby Huang），钙信号（Shama Prasada），核糖体（Kunimasa Ohta）和可变剪接（Chonghui Cheng）在EMT中的作用，以及靶向EMT的新进展（Steven Goossens）。这些论文反映了我们的领域在生物系统（发育，修复和疾病，特别是癌症）方面的连续性，但也从基本的理解，分子调控，预后价值和治疗靶向的潜力。他们为进一步的发展奠定了基础，并提供了一个背景框架，我们期待在TEMTIX-X上听到这一消息，由于COVID-19，TEMTIX-X已被重新安排在2022年秋季的巴黎举行。
Continuing a long-standing tradition and relationship, it is a pleasure to introduce this new Cells Tissues Organs Special Issue arising from the most recent 9th TEMTIA meeting at Kumamoto University, Kumamoto, Japan, held from November 11 to 14, 2019. This was the 1st TEMTIA meeting in Japan and a great opportunity to hear more from the epithelial-mesenchymal transition (EMT)-rich nation and be updated internationally. Forty-eight speakers (27 invited and 21 selected from abstract submissions) and 170 total delegates from 20 countries or regions (Australia, Belgium, China, France, Germany, Hong Kong, India, Ireland, Israel, Japan, Korea, Malaysia, Poland, Singapore, Spain, Sweden, Switzerland, Taiwan, the UK, and the USA) enjoyed the beautiful, interesting, and inspiring surrounds to share in a rich diversity of talks bridging the major EMT disciplines of Development, Cell, Cancer, and Fibrosis, as is the TEMTIA charter (https://temtia. org/Home/About#). These meetings provide an excellent opportunity to share both methodological developments and new knowledge arising in these different themes.Many of the current and topical themes are represented in the manuscripts contained within this Special Issue, and we express our gratitude to the authors and reviewers. A somewhat nostalgic walk down memory lane in the form of a virtual interview by Guojun Sheng of Rik Thompson, Don Newgreen, and Hans-Werner Denker sets the scene for the cross-disciplinary contributions ranging from the conserved roles of netrins in development and wound healing (Michael Murray), EMT biomarkers in cancer (Christine Gilles)–especially the hybrid state (Rik Thompson), OVOL1 and 2 drivers in development, disease, and reprogramming (Mohit Kumar Jolly), novel use of the chick chorioallantoic membrane (CAM) as an alternative model for cancer EMT studies (Ruby Huang), the roles of calcium signaling (Shama Prasada), ribosomes (Kunimasa Ohta), and alternative splicing (Chonghui Cheng) in EMT, and new developments in targeting EMT (Steven Goossens). These papers reflect the continuum that our field enjoys in terms of both the biological systems (development, repair, and disease–especially cancer), but also from the basic understanding, molecular regulation, prognostic value, and potential for therapeutic targeting. They set the scene and provide a contextual framework for further developments, which we look forward to hearing about at TEMTIX-X, which has been rescheduled for Paris in Autumn 2022 due to COVID-19.