Serum leptin levels in hypo- and hyperthyroidism
Serum leptin levels in hypo- and hyperthyroidism
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DOI：
10.1677/joe.0.1570075
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发表时间：
1998-04-01
影响因子：
4
通讯作者：
Ramadori, G
中科院分区：
文献类型：
--
作者：
Leonhardt, U;Ritzel, U;Ramadori, G
瘦素是ob基因的产物，是调节体重的重要循环信号。在本研究中，免疫反应性瘦素（leptin-IR）的作用进行了调查，在功能性甲状腺疾病。对23例甲状腺功能减退症和19例甲状腺功能亢进症患者血清瘦素-IR水平进行了比较，并与21例对照组进行了比较。通过特异性RIA定量瘦素-IR。在甲亢患者中，瘦素-IR与对照组无差异。甲状腺功能减退患者血清瘦素-IR水平显著升高（21.0 +/- 2.7 μ g/l vs对照组10.8 +/- 2.1 μ g/l，P=0.0044）。当甲状腺功能减退症患者的血清瘦素与甲状腺功能正常的对照相同的身体质量指数的差异仍然显着（P=0.0333配对学生的t检验）。这可能表明血清瘦素水平的升高不仅反映了继发于甲状腺功能减退的体重变化，而且可能增加以克服甲状腺功能减退引起的体重增加。
Leptin, the product of the ob gene, is an important circulating signal for the regulation of body weight. In the present study the role of immunoreactive leptin (leptin-IR) was investigated in functional thyroid disease. Serum leptin-IR levels of 23 hypothyroid and 19 hyperthyroid patients were compared with 21 controls. Leptin-IR was quantified by a specific RIA. In hyperthyroid patients, leptin-IR was not different from controls. Serum leptin-IR levels were significantly increased in hypothyroid patients (21.0 +/- 2.7 mu g/l vs controls 10.8 +/- 2.1 mu g/l, P=0.0044). When serum leptin of hypothyroid patients was compared with euthyroid controls of the same body mass index the difference was still significant (P=0.0333 by paired Student's t-test). This might indicate that elevation of the serum leptin level does not merely reflect changes in body weight secondary to hypothyroidism, but might be increased to overcome the gain of body weight caused by hypothyroidism.