Uveal and capsular biocompatibility of an intraocular lens with a hydrophilic anterior surface and a hydrophobic posterior surface
Uveal and capsular biocompatibility of an intraocular lens with a hydrophilic anterior surface and a hydrophobic posterior surface
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具有亲水性前表面和疏水性后表面的人工晶状体的葡萄膜和囊生物相容性
DOI：
10.1016/j.jcrs.2009.09.027
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发表时间：
2010-02-01
影响因子：
2.8
通讯作者：
Wang, Yao
中科院分区：
文献类型：
--
作者：
Huang, Xiao-Dan;Yao, Ke;Wang, Yao
目得：目的：评价前表面亲水后表面疏水的人工晶状体（intraocular lenses，IOL）的葡萄膜和囊膜生物相容性。单位：浙江大学医学院附属第二医院眼科中心。接触角测试表征了IOL表面的亲水性;物理和光学性质根据国家食品药品监督管理局（SFDA）标准测定。对家兔进行超声乳化术并植入改良硅胶IOL、对照硅胶IOL或水凝胶IOL。通过测量房水闪光来评估术后炎症，并通过软件分析来评估PCO。术后3个月，光学显微镜下观察人工晶状体表面的粘附细胞，三宅苹果法观察PCO。球的组织切片用于评估透镜上皮细胞（LECs）和囊袋中的细胞外基质。结果：接触角数据显示MPC改性IOL具有亲水性前表面和疏水性后表面。改良后的人工晶状体性能符合SFDA标准。在任何时间，IOL组之间的房水闪光均无统计学差异。改良和对照组的后囊膜混浊均少于水凝胶组（P
PURPOSE: To evaluate the uveal and capsular biocompatibility of intraocular lenses (IOLs) with a hydrophilic anterior surface and a hydrophobic posterior surface in a rabbit model.SETTING: Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, China.METHODS: Modified silicone IOLs were produced by grafting 2-methacryloyloxyethyl phosphorylcholine (MPC) onto the anterior IOL surface using a plasma technique. A contact-angle test characterized the hydrophilicity of the IOL surface; physical and optical properties were determined by State Food and Drug Administration (SFDA) standards. Rabbits had phacomulsification and implantation a modified silicone IOL, a control silicone IOL, or a hydrogel IOL. Postoperative inflammation was assessed by aqueous flare measurement, and PCO was evaluated by software analysis. Three months after surgery, attached cells on extracted IOLs were evaluated by light microscopy; PCO was evaluated by Miyake-Apple technique. Histologic sections of globes were used to assess lens epithelial cells (LECs) and extracellular matrix in the capsular bag.RESULTS: Contact angle data showed the MPC-modified IOL had a hydrophilic anterior surface and hydrophobic posterior surface. The properties of the modified IOLs met SFDA standards. There was no statistical difference in aqueous flare between the IOL groups at any time. The modified and control IOLs had less PCO than the hydrogel IOLs (P