HISTOLOGICAL-EVALUATION OF A BIODEGRADABLE POLYACTIVE(R)/HYDROXYAPATITE MEMBRANE
HISTOLOGICAL-EVALUATION OF A BIODEGRADABLE POLYACTIVE(R)/HYDROXYAPATITE MEMBRANE
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DOI：
10.1016/0142-9612(95)94142-8
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发表时间：
1995-07-01
期刊：
影响因子：
14
通讯作者：
PAQUAY, YGGJ
中科院分区：
文献类型：
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作者：
JANSEN, JA;DERUIJTER, JE;PAQUAY, YGGJ
引导组织再生（GTR）是一种用于治疗与牙周病或牙种植体相关的骨缺损的技术。在GTR的大多数实验研究中，使用不可降解的膜。此类装置固有的缺点是，在伤口愈合结束或过程中，必须将其移除。因此，本研究的目的是研究一种新的可生物降解的膜材料用于GTR，它也具有优异的机械性能和生物相容性。该材料是由聚（对苯二甲酸乙二醇酯）和聚（对苯二甲酸丁二醇酯）嵌段共聚物（PEG/PBT）组成的复合材料，其以纯形式用于实验，并与羟基磷灰石（HA）颗粒混合。对山羊进行了皮下和龈下植入研究，以确定其中几种材料的生物相容性和生物降解性特征。介绍了材料之间在生产工艺、PEG/PBT比例、材料厚度和HA存在方面的差异。植入期分别为3、6和12周。组织学结果表明，所有研究的材料与周围组织具有生物相容性。膜的降解伴随着温和的细胞反应。降解过程主要受PEG/PET比例的影响。较高的PET含量导致降解减少。
Guided tissue regeneration (GTR) is a technique which is used for the treatment of bone defects associated with periodontal disease or enossal dental implants. In most experimental studies on GTR, non-degradable membranes are used. A drawback inherent to such devices is that at the end or in the course of the wound healing they have to be removed. Therefore, the aim of the present study was to investigate a new biodegradable membrane material for use in GTR, which also has excellent mechanical properties and is biocompatible. The material is a composite consisting of poly(ethyleneglycol terephthalate) and poly(butylene terephthalate) segmented copolymer (PEG/PBT), which for the experiments was used in pure form and also mixed with hydroxyapatite (HA) grains. Subcutaneous and subgingival implantation studies in goats were performed to determine the biocompatibility and biodegradability characteristics of several of these materials. Differences between materials were introduced in the production process, PEG/PBT ratio, material thickness and presence of HA. Implantation periods were 3, 6 and 12 wk. The histological results indicated that all investigated materials were biocompatible with the surrounding tissue. Degradation of the membranes was attended by a mild cellular reaction. The degradation process was mainly influenced by the PEG/PET ratio. A higher PET content resulted in a decreased degradation.