Polymer-micelle incarcerated scandium as a polymer-supported catalyst for high-throughput organic synthesis
Polymer-micelle incarcerated scandium as a polymer-supported catalyst for high-throughput organic synthesis
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DOI：
10.1021/ja053176f
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发表时间：
2005-09-28
影响因子：
15
通讯作者：
Kobayashi, S
中科院分区：
文献类型：
--
作者：
Takeuchi, M;Akiyama, R;Kobayashi, S
一种新的固定化技术Sc（OTf）3，聚合物胶束嵌顿（PMI）的方法，已经开发出来。PMI Sc（OTf）3在几个基本的碳-碳键形成反应中具有高度活性。催化剂通过简单过滤定量回收，并重复使用数次而不损失催化活性，并且在所有反应中均未观察到Sc浸出（<0.1ppm）。此外，几种溶剂是可用的，并且这些方面适合于高通量有机合成（HTOS）。据我们所知，这是利用聚合物胶束固定刘易斯酸的第一个例子。
A novel immobilization technique for Sc(OTf)3, a polymer−micelle incarcerated (PMI) method, has been developed. PMI Sc(OTf)3is highly active in several fundamental carbon−carbon bond-forming reactions. The catalyst is recovered quantitatively by simple filtration and reused several times without loss of catalytic activity, and no Sc leaching was observed in all reactions (<0.1 ppm). In addition, several solvents are available, and these aspects are suitable for high-throughput organic synthesis (HTOS). To the best of our knowledge, this is the first example of immobilization of Lewis acids utilizing polymer micelles.